Results 281 to 290 of about 2,768,548 (336)

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Sperm DNA methylation profiling in patients with Kallmann syndrome. [PDF]

Endocr Connect
Wang R, Li X, Zhang J, Wang X, Mao J, Feng X, Wang S, Li Y, Wu X, Guo Y.   +9 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs. [PDF]

Stat Med
Gansou Y, Oualkacha K, Angela Cremona M, Lakhal-Chaieb L.   +3 more
europepmc   +1 more source

DNA methylations : A comparison of four genes between Red Junglefowl and White Leghorn

, 2011
Johan Bélteky
openalex   +1 more source

MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta

, 2018
Zhengwei Yuan, Qi Chen, Yi Guo, Wei Ma, Jia Xue, Weilin Wang   +5 more
openalex   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

DNA methylation-based clocks, tobacco smoking, and lung cancer risk. [PDF]

BMC Med
Penha RCC, Onwuka JU, Langdon R, Sandanger TM, Nøst TH, Vineis P, Johansson M, Milne RL, Dugué PA, Relton C, Suderman M, McKay J, Johansson M.   +12 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

The role of placental DNA methylation in the pathogenesis of chronic intervillositis of unknown etiology. [PDF]

Clin Epigenetics
Inkster AM, Peñaherrera MS, Robinson WP, Terry J.   +3 more
europepmc   +1 more source