Results 211 to 220 of about 2,516,689 (307)

Genetic and epigenetic landscape of O⁶-methylguanine-DNA methyltransferase (MGMT): implications for DNA repair and cancer therapeutics. [PDF]

Explor Target Antitumor Ther
Singh S, Nema R, Banerjee M, Kushwah AS.
europepmc   +1 more source

Chromosome‐level genome and methylome of vine tea suggest roles for tandem duplication and CHH hypomethylation in high dihydromyricetin accumulation

iMetaOmics, EarlyView.
A chromosome‐level genome assembly and single‐base resolution methylome of vine tea (Nekemias grossedentata) reveal that lineage‐specific tandem duplications of dihydromyricetin (DHM) biosynthetic genes (NgCHS and NgF3′5′ H) have expanded their copy numbers, providing the genetic basis for high DHM flux.
Yingmei Wu, Hanrui Hu, Qing Ye, Xueqing Chen, Miyuan Tian, Jing Li, Li Lu, Yifei Liu, Yi Shang, Yanling Li, Xingyao Xiong, Junbo Gou   +11 more
wiley   +1 more source

Characterization and differential expression of DNA methyltransferase and demethylase genes in response to abiotic stress in Isodon rubescens. [PDF]

BMC Plant Biol
Zhang X, Zhu L, Xu Z, Wang Z, Dai L.
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties. [PDF]

J Med Chem
Zwergel C, Lambona C, Fioravanti R, Raucci A, Fiorentino F, Nchugoua Tchieh G, Jallet C, Lacroix L, Pierrettori M, Pellegrini FR, Xiong Y, Jin J, Arimondo P, Trisciuoglio D, Mai A, Valente S.   +15 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Preclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy. [PDF]

Neurooncol Adv
Mishra DK, Morris SM, Popovski D, Girard EJ, Bondoc A, Senthil Kumar S, Andrade AF, Zhu X, Yao F, Brusniak MY, Umaru B, Crotty EE, Brasel K, Pakiam F, Russo C, Zeinieh M, Biery MC, Coxon M, Conti H, Clarke M, Lu M, Rutka J, Llivichuzhca-Loja D, Konnikova L, Fouladi M, Jabado N, Huang A, Olson JM, Drissi R.   +28 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

MGMTai: O6-methylguanine-DNA methyltransferase (<i>MGMT</i>) methylation prediction in isocitrate dehydrogenase (<i>IDH</i>)-wild type glioblastoma to direct temozolomide therapy. [PDF]

Neurooncol Adv
Pittman P, Sun C, Samec T, Davidson C, Bryant D, Alnahhas I, Glantz M, Hahn-Lowry R, Spetzler D, Magee D, Nicolaides T.   +10 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source