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DNA modification by methyltransferases
Current Opinion in Structural Biology, 1995Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes. Structural study of the HhaI DNA methyltransferase has provided considerable insight into the chemistry of C5-cytosine methylation. The DNA-protein complex reveals a substrate cytosine flipped out of the double helix during the reaction, and a novel two-loop DNA ...
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DNA Methyltransferases in Hematologic Malignancies
Seminars in Hematology, 2013DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays an important role in epigenetically regulated gene expression and repression. Mouse models with conditional knockout of the DNA methyltransferase 1 (DNMT1) and DNA methyltransferase 3A (DNMT3A) genes have revealed a role of DNA methylation in mediating the self ...
Keqin Kathy, Li +5 more
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Chemistry and Biology of DNA Methyltransferases
Critical Reviews in Biochemistry and Molecular Biology, 1996Recognition of a specific DNA sequence by a protein is probably the best example of macromolecular interactions leading to various events. It is a prerequisite to understanding the basis of protein-DNA interactions to obtain a better insight into fundamental processes such as transcription, replication, repair, and recombination. DNA methyltransferases
Ahmad, I, Rao, DN
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Coupling of a Nucleoside with DNA by a Methyltransferase
Angewandte Chemie International Edition, 1998How to outwit a methyltransferase: Methyltransferases (Mtases) catalyze the transfer of the activated methyl group from the cofactor S-adenosyl-L-methionine (1) to acceptors R within a large variety of biomolecules. Through the use of the cofactor analogue 2 a whole nucleoside was coupled to DNA in a Mtase-catalyzed reaction.
Marc, Pignot +3 more
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The Role of DNA Methylation and DNA Methyltransferases in Cancer
2022The malignant transformation of normal cells is driven by both genetic and epigenetic changes. With the advent of next-generation sequencing and large-scale international consortia, it is now possible to profile the genomes and epigenomes of thousands of primary tumors from nearly every cancer type.
Daniel J, Weisenberger +2 more
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Enzymology of Mammalian DNA Methyltransferases
2016DNA methylation is a hot topic in basic and biomedical research. Despite tremendous progress in understanding the structures and biochemical properties of the mammalian DNA methyltransferases (DNMTs), principles of their targeting and regulation in cells have only begun to be uncovered.
Renata Z, Jurkowska, Albert, Jeltsch
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Targeting DNA methyltransferase in cancer
Cancer and Metastasis Reviews, 1998DNA methyltransferase is an enzyme responsible for generating and maintaining DNA methylation patterns. DNA methylation patterns control different genome functions, thus they are an important component of the epigenetic information. It has been recently postulated that DNA methyltransferase plays an important role in oncogenesis and that it is a ...
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Application of DNA methyltransferases in targeted DNA methylation
Applied Microbiology and Biotechnology, 2007DNA methylation is an essential epigenetic modification. In bacteria, it is involved in gene regulation, DNA repair, and control of cell cycle. In eukaryotes, it acts in concert with other epigenetic modifications to regulate gene expression and chromatin structure.
Albert, Jeltsch +5 more
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DNA Methyltransferases in Mammalian Oocytes
2017Epigenetic mechanisms play important roles in properly occurring mammalian oogenesis. One of these mechanisms is DNA methylation adding a methyl group to the fifth carbon atom of the cytosine residues using S-adenosyl-L-methionine as a methyl donor. DNA methylation generally takes place at cytosine-phosphate-guanine (CpG) dinucleotide sites and rarely ...
Fatma, Uysal, Saffet, Ozturk
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Cloning of a mammalian DNA methyltransferase
Gene, 1988Cloning and sequencing of cDNA clones has shown that mammalian DNA (cytosine-5)-methyltransferase comprises a 1000-amino acid (aa) N-terminal region of unknown function and a 570-aa C-terminal region that is clearly related to bacterial type-II cytosine restriction methyltransferases.
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