Results 261 to 270 of about 259,719 (301)
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DNA Methyltransferases in Hematologic Malignancies
Seminars in Hematology, 2013DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays an important role in epigenetically regulated gene expression and repression. Mouse models with conditional knockout of the DNA methyltransferase 1 (DNMT1) and DNA methyltransferase 3A (DNMT3A) genes have revealed a role of DNA methylation in mediating the self ...
Keqin Kathy, Li +5 more
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DNA Methyltransferases: Facts, Clues, Mysteries
2006DNA methylation plays a pivotal role during development in mammals and is central to transcriptional silencing. The DNA methyltransferases (DNMTs) are responsible for the generation of genomic methylation patterns leading to gene silencing, but the underlying molecular basis remains largely shrouded in mystery.
Brenner, Carmen, Fuks, François
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Methyltransferase-Directed DNA Strand Scission
Journal of the American Chemical Society, 2005We demonstrate here that MTase-modified DNA can undergo the Staudinger ligation with triarylphosphines derivatized with phenanthroline. Presentation of these duplexes with Cu(II) and 3-mercaptopropionic acid leads to strand scission proximal to the MTase recognition site.
Lindsay R, Comstock, Scott R, Rajski
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DNA Methyltransferase Inhibitors
2007Regional hypermethylation and global hypomethylation coexist in cancer cells. Under-standing the mechanisms responsible for global hypomethylation and regional hypermethylation in cancer is required for the proper design of therapeutic strategies targeting the DNA methylation machinery.
Gregory K. Reid, A. Robert MacLeod
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Targeting DNA methyltransferase in cancer
Cancer and Metastasis Reviews, 1998DNA methyltransferase is an enzyme responsible for generating and maintaining DNA methylation patterns. DNA methylation patterns control different genome functions, thus they are an important component of the epigenetic information. It has been recently postulated that DNA methyltransferase plays an important role in oncogenesis and that it is a ...
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DNA Methyltransferases Inhibitors from Natural Sources
Current Topics in Medicinal Chemistry, 2015DNA methyltransferases (DNMTs) catalyze the methylation at cytosine-C5 mainly in a CpG dinucleotide context. Although DNA methylation is essential for fundamental processes like embryonic development or differentiation, aberrant expression and/or activities of DNMTs are involved in several pathologies, from neurodegeneration to cancer. DNMTs inhibition
ZWERGEL, CLEMENS +2 more
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Enzymology of Mammalian DNA Methyltransferases
2016DNA methylation is a hot topic in basic and biomedical research. Despite tremendous progress in understanding the structures and biochemical properties of the mammalian DNA methyltransferases (DNMTs), principles of their targeting and regulation in cells have only begun to be uncovered.
Renata Z, Jurkowska, Albert, Jeltsch
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DNA Methyltransferases in Mammalian Oocytes
2017Epigenetic mechanisms play important roles in properly occurring mammalian oogenesis. One of these mechanisms is DNA methylation adding a methyl group to the fifth carbon atom of the cytosine residues using S-adenosyl-L-methionine as a methyl donor. DNA methylation generally takes place at cytosine-phosphate-guanine (CpG) dinucleotide sites and rarely ...
Fatma, Uysal, Saffet, Ozturk
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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