Results 81 to 90 of about 259,719 (301)

Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. [PDF]

, 2018
5-Hydroxymethylcytosine (5hmC) is produced from 5-methylcytosine (5mC) by Ten-eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation.
Apró, Anna, Arányi, Tamás, Bacquet, Caroline, Hathy, Edit, Kiss, Judit, Réthelyi, János M., Szabó, Pál, Szeri, Flóra, Szüts, Dávid, Vető, Borbála   +9 more
core   +4 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Somatic mutations, DNA methylation, and expression of DNA repair genes in Arabidopsis thaliana treated with 5-azacytidine

Biologia Plantarum, 2019
An inhibitor of DNA methylation 5-azacytidine (5A) is a chemical analog of the nucleoside cytidine. This study investigated the influence of 5A-induced DNA hypomethylation on the accumulation of somatic DNA mutations (nucleotide substitutions, indels) in
K.V. Kiselev, Z.V. Ogneva, A.S. Dubrovina, N.N. Nityagovsky, A.R. Suprun   +4 more
doaj   +1 more source

Phylogeny, expression patterns and regulation of DNA Methyltransferases in early development of the flatfish, Solea senegalensis [PDF]

, 2017
Background: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish.
Armesto, Paula, Campinho, Marco António, Carballo, Carlos, Firmino, Joana, Manchado, Manuel, Power, Deborah M.   +5 more
core   +2 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma

Acta Neuropathologica Communications
DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer.
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata   +13 more
doaj   +1 more source

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]

, 2011
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh, A Nomoto, A Pichlmair, AM Waterhouse, B Morin, Benjamin W Neuman, BS Schnierle, Burkhard Ludewig, CA Janeway Jr., DJ Hui, E Decroly, EJ Snijder, F Terenzi, G Bocharov, G Uzé, H Hemmi, H Kato, H Zhou, J Reguera, JK Roth-Cross, John Ziebuhr, K Bryson, K Karikó, KK Eriksson, KM Rose, Kristy J Szretter, L Cervantes-Barragan, L Cervantes-Barragán, L Gitlin, Luisa Cervantes-Barragan, M Bouvet, M Feder, M Schlee, Matthias Habjan, Michael S Diamond, O Haller, O Le Gall, O Takeuchi, R Gosert, R Züst, Reinhard Maier, Roland Züst, S Daffis, S Shuman, S Wünschmann, SR Nallagatla, SR Nallagatla, Stuart G Siddell, Susan C Baker, V Hornung, V Thiel, Volker Thiel, Winfried Barchet, Y Chen, YM Loo, YM Loo   +55 more
core   +1 more source

REBASE--restriction enzymes and DNA methyltransferases [PDF]

Nucleic Acids Research, 2004
REBASE is a comprehensive database of information about restriction enzymes, DNA methyltransferases and related proteins involved in restriction-modification. It contains both published and unpublished work with information about recognition and cleavage sites, isoschizomers, commercial availability, crystal and sequence data.
Roberts, Richard J., Vincze, Tamas, Posfai, Janos, Macelis, Dana   +3 more
openaire   +2 more sources

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

Advanced Materials Interfaces, EarlyView.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu, Matthew K. Burgess, Catarina Franco Jones, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Sidahmed Abayzeed, Paola Sanjuán‐Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu   +14 more
wiley   +1 more source

Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch

SLAS Discovery
Methylation of proteins and nucleic acids plays a fundamental role in epigenetic regulation, and discovery of methyltransferase (MT) inhibitors is an area of intense activity.
Ha Pham, Meera Kumar, Anibal Ramos Martinez, Mahbbat Ali, Robert G. Lowery   +4 more
doaj   +1 more source