Results 121 to 130 of about 141,545 (201)

Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. [PDF]

Epigenetics Chromatin, 2017
Ribas L, Vanezis K, Imués MA, Piferrer F, Piferrer F.   +4 more
europepmc   +1 more source

Novel antibiotics from DNA adenine methyltransferase inhibitors

, 2011
The re-emergence of plague as a world-wide health concern and the potential risk posed by bioterrorism has led to an increased interest in available treatments for the disease. The bacterial DNA adenine-N6 methyltransferase, Dam, is involved in the regulation of a range of pathogenic bacteria and has been validated as a target for the development of ...
openaire   +1 more source

Transcriptome Profiling Reveals Transcriptional Regulation by DNA Methyltransferase Inhibitor 5-Aza-2'-Deoxycytidine Enhancing Red Pigmentation in Bagged "Granny Smith" Apples (Malus domestica). [PDF]

Int J Mol Sci, 2018
Ma C, Liang B, Chang B, Liu L, Yan J, Yang Y, Zhao Z.   +6 more
europepmc   +1 more source

Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor. [PDF]

Genomics, 2019
Wang X, Ao H, Song M, Bai L, He W, Wang C, Yu Y.   +6 more
europepmc   +1 more source

Novel antibiotics from DNA adenine methyltransferase inhibitors

, 2009
DNA adenine methylation plays a role in several core bacterial processes, including DNA mismatch repair, the timing of DNA replication and gene expression. The dependence of bacterial virulence on the activity of Dam, an adenine methyltransferase, makes it an attractive target for novel antibiotics. Dam from Yersinia pestis, the plague causing bacteria,
openaire   +1 more source

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS. [PDF]

FASEB J
Weng Y, Shangguan L, Shen Q, Zhu Z, Zhang Y, Zhang J, Yan G, Shen S, Xiang Z, Ruan J, Wen Y, Wang D, Wang Y.   +12 more
europepmc   +1 more source

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor. [PDF]

Oncotarget, 2015
Gayet O, Loncle C, Duconseil P, Gilabert M, Lopez MB, Moutardier V, Turrini O, Calvo E, Ewald J, Giovannini M, Gasmi M, Bories E, Barthet M, Ouaissi M, Goncalves A, Poizat F, Raoul JL, Secq V, Garcia S, Viens P, Dusetti N, Iovanna J.   +21 more
europepmc   +1 more source

Targeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer. [PDF]

Exp Hematol Oncol
Zhu Y, Liu K, Zhu H.
europepmc   +1 more source