Results 1 to 10 of about 259,719 (301)

Cytosine-to-uracil deamination by SssI DNA methyltransferase. [PDF]

PLoS ONE, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Ildikó Stier, Antal Kiss
doaj   +18 more sources

Genome-Wide Identification and Expression Pattern Analysis of the DNA Methyltransferase Gene Family Revealed the DNA Methylation Response to Tapping in Rubber Tree [PDF]

Plants
DNA methylation is an epigenetic modification that plays a crucial role in the regulation of gene expression, genome defense, and numerous biological processes.
Yuanyuan Hao, Bin Hu, Yongkang Xue, Xuelian Li, Kun Wang, Xuemei Dai, Zhifu Guo, Xiangyu Long   +7 more
doaj   +2 more sources

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification [PDF]

JACC: Basic to Translational Science
Summary: Aortic stenosis (AS) is a severe heart valve disease marked by calcification, leading to heart failure. This study examined mitochondrial function in human aortic valve interstitial cells isolated from patients with AS and tested spermidine, an ...
Naaleum Song, PhD, Eunhye Ji, PhD, Jeong Eun Yu, BS, Kyoung-Hee Choi, BS, Dae-Hee Kim, MD, PhD, Jong-Min Song, MD, PhD, Duk-Hyun Kang, MD, PhD, Jae-Kwan Song, MD, PhD, Jiyoung Yu, PhD, Kyunggon Kim, PhD, Sahmin Lee, MD, PhD, Elena Aikawa, MD, PhD   +11 more
doaj   +2 more sources

Increased Expression of DNA Methyltransferase 1 and 3B Correlates with Tumor Grade in Laryngeal Squamous Cell Carcinoma [PDF]

Pharmaceutical Sciences, 2021
Background: DNA methyltransferase (DNMT) enzymes, encoded by DNMT1, DNMT3A andDNMT3B genes, play a major role in the development of cancers through aberrant promotermethylation.
Nooshin Mohammadzadeh, Fatemeh Mosaffa, Ehsan Khadivi, Rosa Jahangiri, Khadijeh Jamialahmadi   +4 more
doaj   +1 more source

Recent progress in DNA methyltransferase inhibitors as anticancer agents

Frontiers in Pharmacology, 2022
DNA methylation mediated by DNA methyltransferase is an important epigenetic process that regulates gene expression in mammals, which plays a key role in silencing certain genes, such as tumor suppressor genes, in cancer, and it has become a promising ...
Zhixiong Zhang, Zhixiong Zhang, Guan Wang, Yuyan Li, Yuyan Li, Dongsheng Lei, Jin Xiang, Liang Ouyang, Liang Ouyang, Yanyan Wang, Yanyan Wang, Jinliang Yang   +11 more
doaj   +1 more source

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]

, 2013
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman, Du, Jiamu, Feng, Suhua, Jacobsen, Steven E, Johnson, Lianna, Patel, Dinshaw J, Stroud, Hume, Zhong, Xuehua   +7 more
core   +5 more sources

A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand.

PLoS ONE, 2022
5-Methylcytosine is one of the major epigenetic marks of DNA in living organisms. Some bacterial species possess DNA methyltransferases that modify cytosines on both strands to produce fully-methylated sites or on either strand to produce hemi-methylated
Yoshikazu Furuta, Fumihito Miura, Takahiro Ichise, Shouta M M Nakayama, Yoshinori Ikenaka, Tuvshinzaya Zorigt, Mai Tsujinouchi, Mayumi Ishizuka, Takashi Ito, Hideaki Higashi   +9 more
doaj   +1 more source

Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity

Frontiers in Genetics, 2023
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior.
Snežana Smederevac, Lissette Delgado-Cruzata, Dušanka Mitrović, Bojana M. Dinić, Toni-Ann T. Bravo, Maria Delgado, Vojislava Bugarski Ignjatović, Selka Sadiković, Ilija Milovanović, Nataša Vučinić, Bojan Branovački, Mechthild Prinz, Zoran Budimlija, Jelena Kušić‐Tišma, Željka Nikolašević   +14 more
doaj   +1 more source

Leptin DNA Methylation and Its Association with Metabolic Risk Factors in a Northwest Indian Obese Population

Journal of Obesity & Metabolic Syndrome, 2021
Background : It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines.
Sadashiv, Anupama Modi, Manoj Khokhar, Praveen Sharma, Rajnish Joshi, Sudhanshu Shekhar Mishra, Rajay N Bharshankar, Sunita Tiwari, Pankaj Kumar Singh, Vivek Vidyadhar Bhosale, Mahendra Pal Singh Negi   +10 more
doaj   +1 more source

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]

, 2012
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Garelnabi, EAE, Hartley, JA, Karodia, N, Kiakos, K, Li, L, Phillips, Roger, Pletsas, D, Wheelhouse, RT   +7 more
core   +1 more source