Results 1 to 10 of about 2,516,590 (210)

Recent progress in DNA methyltransferase inhibitors as anticancer agents

Frontiers in Pharmacology, 2022
DNA methylation mediated by DNA methyltransferase is an important epigenetic process that regulates gene expression in mammals, which plays a key role in silencing certain genes, such as tumor suppressor genes, in cancer, and it has become a promising ...
Zhixiong Zhang, Zhixiong Zhang, Guan Wang, Yuyan Li, Yuyan Li, Dongsheng Lei, Jin Xiang, Liang Ouyang, Liang Ouyang, Yanyan Wang, Yanyan Wang, Jinliang Yang   +11 more
doaj   +2 more sources

DNA Methyltransferase [PDF]

Science-Business eXchange, 2020
A sensitive method was devised to monitor the in vitro binding of nuclear proteins from HeLa cells presumably to the major groove of DNA. Upon the incubation of DNA with nuclear extracts, the complexed DNA was incubated with the CpG DNA methyltransferase
S. Kochanek, D. Renz, W. Doerfler
semanticscholar   +4 more sources

Genome-Wide Identification and Expression Pattern Analysis of the DNA Methyltransferase Gene Family Revealed the DNA Methylation Response to Tapping in Rubber Tree [PDF]

Plants
DNA methylation is an epigenetic modification that plays a crucial role in the regulation of gene expression, genome defense, and numerous biological processes.
Yuanyuan Hao, Bin Hu, Yongkang Xue, Xuelian Li, Kun Wang, Xuemei Dai, Zhifu Guo, Xiangyu Long   +7 more
doaj   +2 more sources

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification [PDF]

JACC: Basic to Translational Science
Summary: Aortic stenosis (AS) is a severe heart valve disease marked by calcification, leading to heart failure. This study examined mitochondrial function in human aortic valve interstitial cells isolated from patients with AS and tested spermidine, an ...
Naaleum Song, PhD, Eunhye Ji, PhD, Jeong Eun Yu, BS, Kyoung-Hee Choi, BS, Dae-Hee Kim, MD, PhD, Jong-Min Song, MD, PhD, Duk-Hyun Kang, MD, PhD, Jae-Kwan Song, MD, PhD, Jiyoung Yu, PhD, Kyunggon Kim, PhD, Sahmin Lee, MD, PhD, Elena Aikawa, MD, PhD   +11 more
doaj   +2 more sources

Light‐Activation of DNA‐Methyltransferases [PDF]

Angewandte Chemie International Edition, 2021
Abstract5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis.
Jan Wolffgramm, Benjamin Buchmuller, Shubhendu Palei, Álvaro Muñoz‐López, Julian Kanne, Petra Janning, Michal R. Schweiger, Daniel Summerer   +7 more
openaire   +6 more sources

Increased Expression of DNA Methyltransferase 1 and 3B Correlates with Tumor Grade in Laryngeal Squamous Cell Carcinoma [PDF]

Pharmaceutical Sciences, 2021
Background: DNA methyltransferase (DNMT) enzymes, encoded by DNMT1, DNMT3A andDNMT3B genes, play a major role in the development of cancers through aberrant promotermethylation.
Nooshin Mohammadzadeh, Fatemeh Mosaffa, Ehsan Khadivi, Rosa Jahangiri, Khadijeh Jamialahmadi   +4 more
doaj   +1 more source

DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

Clinical Epigenetics, 2021
DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses.
Chunhong Hu, Xiaohan Liu, Yue Zeng, Junqi Liu, Fang Wu   +4 more
semanticscholar   +1 more source

DNA methylation and DNA methyltransferases [PDF]

Epigenetics & Chromatin, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding mammalian genes was believed to be at least five times greater than the actual number, and when it was ...
John R. Edwards, Olya Yarychkivska, Mathieu Boulard, Timothy H. Bestor   +3 more
openaire   +5 more sources

A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand.

PLoS ONE, 2022
5-Methylcytosine is one of the major epigenetic marks of DNA in living organisms. Some bacterial species possess DNA methyltransferases that modify cytosines on both strands to produce fully-methylated sites or on either strand to produce hemi-methylated
Yoshikazu Furuta, Fumihito Miura, Takahiro Ichise, Shouta M M Nakayama, Yoshinori Ikenaka, Tuvshinzaya Zorigt, Mai Tsujinouchi, Mayumi Ishizuka, Takashi Ito, Hideaki Higashi   +9 more
doaj   +1 more source

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

Frontiers in Oncology, 2020
Chemoresistance has been a significant problem affecting the efficacy of drugs targeting tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating ...
Wei Yu, Lili Zhang, Q. Wei, Anwen Shao
semanticscholar   +1 more source