Results 31 to 40 of about 259,719 (301)

MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells

Cell Reports, 2018
Summary: Mapping the binding sites of DNA- or chromatin-interacting proteins is essential to understanding biological processes. DNA adenine methyltransferase identification (DamID) has emerged as a comprehensive method to map genome-wide occupancy of ...
Michal Sobecki, Charbel Souaid, Jocelyne Boulay, Vincent Guerineau, Daan Noordermeer, Laure Crabbe   +5 more
doaj   +1 more source

On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.

PLoS ONE, 2011
The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA ...
Tomasz P Jurkowski, Albert Jeltsch
doaj   +1 more source

DNA Methyltransferases, DNA Damage Repair, and Cancer [PDF]

, 2012
The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation, catalyzed by the DNMTs, plays an important role in maintaining genome stability. Aberrant expression of DNMTs and disruption of DNA methylation patterns are closely associated with many forms ...
Bilian, Jin, Keith D, Robertson
openaire   +2 more sources

Recurrent acral ulcerations associated with DNA methyltransferase 1-complex disorder

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022
DNA methyltransferase 1, encoded by DNMT gene, is a crucial DNA methyltransferase with essential roles in transcription regulation, gene imprinting, and cell differentiation.
Diogo Cerejeira, Frederico Bonito, Cristina Ionel, Henriqueta Cunha, Pedro Pereira   +4 more
doaj  

MamA essentiality in Mycobacterium smegmatis is explained by the presence of an apparent cognate restriction endonuclease

BMC Research Notes, 2020
Objective Restriction-Modification (R-M) systems are ubiquitous in bacteria and were considered for years as rudimentary immune systems that protect bacterial cells from foreign DNA.
Samantha E. Randall, Maria Carla Martini, Ying Zhou, Samantha R. Joubran, Scarlet S. Shell   +4 more
doaj   +1 more source

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

Flexibility of the linker between the domains of DNA methyltransferase SsoII revealed by small-angle X-ray scattering: implications for transcription regulation in SsoII restriction-modification system.

PLoS ONE, 2014
(Cytosine-5)-DNA methyltransferase SsoII (M.SsoII) consists of a methyltransferase domain (residues 72-379) and an N-terminal region (residues 1-71) which regulates transcription in SsoII restriction-modification system.
Petr V Konarev, Galina S Kachalova, Alexandra Yu Ryazanova, Elena A Kubareva, Anna S Karyagina, Hans D Bartunik, Dmitri I Svergun   +6 more
doaj   +1 more source

Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is Therapeutic

Cells, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons (MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the environment, cellular metabolism, and lifestyles.
Lee J. Martin, Danya A. Adams, Mark V. Niedzwiecki, Margaret Wong   +3 more
doaj   +1 more source

Methylation is maintained specifically at imprinting control regions but not other DMRs associated with imprinted genes in mice bearing a mutation in the Dnmt1 intrinsically disordered domain

Frontiers in Cell and Developmental Biology, 2023
Differential methylation of imprinting control regions in mammals is essential for distinguishing the parental alleles from each other and regulating their expression accordingly.
Shaili Regmi, Lana Giha, Ahado Ali, Christine Siebels-Lindquist, Tamara L. Davis   +4 more
doaj   +1 more source

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Berg, Bestor, Bestor, Bestor, Boshart, Bradford, Cedar, de Villiers, Gluzman, Hergersberg, Kingston, Klempnauer, Matthias, Mellon, Morgenstern, Müller, Pfeifer, Pfeifer, Pósfai, Severne   +19 more
core   +1 more source