Results 31 to 40 of about 2,516,689 (307)

Recurrent acral ulcerations associated with DNA methyltransferase 1-complex disorder

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022
DNA methyltransferase 1, encoded by DNMT gene, is a crucial DNA methyltransferase with essential roles in transcription regulation, gene imprinting, and cell differentiation.
Diogo Cerejeira, Frederico Bonito, Cristina Ionel, Henriqueta Cunha, Pedro Pereira   +4 more
doaj  

Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Nature Genetics, 2018
Methylation at the 5 position of cytosine in DNA (5meC) is a key epigenetic mark in eukaryotes. Once introduced, 5meC can be maintained through DNA replication by the activity of ‘maintenance’ DNA methyltransferases (DNMTs). Despite their ancient origin,
Silvana Rošić, R. Amouroux, Cristina E. Requena, A. Gomes, Max Emperle, Toni Beltran, J. Rane, Sarah Linnett, M. Selkirk, Philipp H. Schiffer, A. Bancroft, R. Grencis, A. Jeltsch, P. Hájková, P. Sarkies   +14 more
semanticscholar   +1 more source

DNA methyltransferases hitchhiking on chromatin

Swiss Medical Weekly, 2020
DNA methylation is an epigenetic modification that plays a central regulatory role in various biological processes. Methyl groups are coupled to cytosines by the family of DNA methyltransferases (DNMTs), where DNMT1 is the main maintenance enzyme and the DNMT3 branch of the family is mostly responsible for de novo methylation.
Baubec, Tuncay, Karemaker, Ino D
openaire   +5 more sources

Flexibility of the linker between the domains of DNA methyltransferase SsoII revealed by small-angle X-ray scattering: implications for transcription regulation in SsoII restriction-modification system.

PLoS ONE, 2014
(Cytosine-5)-DNA methyltransferase SsoII (M.SsoII) consists of a methyltransferase domain (residues 72-379) and an N-terminal region (residues 1-71) which regulates transcription in SsoII restriction-modification system.
Petr V Konarev, Galina S Kachalova, Alexandra Yu Ryazanova, Elena A Kubareva, Anna S Karyagina, Hans D Bartunik, Dmitri I Svergun   +6 more
doaj   +1 more source

MamA essentiality in Mycobacterium smegmatis is explained by the presence of an apparent cognate restriction endonuclease

BMC Research Notes, 2020
Objective Restriction-Modification (R-M) systems are ubiquitous in bacteria and were considered for years as rudimentary immune systems that protect bacterial cells from foreign DNA.
Samantha E. Randall, Maria Carla Martini, Ying Zhou, Samantha R. Joubran, Scarlet S. Shell   +4 more
doaj   +1 more source

Cytosine-to-uracil deamination by SssI DNA methyltransferase. [PDF]

PLoS ONE, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Ildikó Stier, Antal Kiss
doaj   +1 more source

Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is Therapeutic

Cells, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons (MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the environment, cellular metabolism, and lifestyles.
Lee J. Martin, Danya A. Adams, Mark V. Niedzwiecki, Margaret Wong   +3 more
doaj   +1 more source

DNA Methyltransferase Activity Assays: Advances and Challenges

Theranostics, 2016
DNA methyltransferases (MTases), a family of enzymes that catalyse the methylation of DNA, have a profound effect on gene regulation. A large body of evidence has indicated that DNA MTase is potentially a predictive biomarker closely associated with ...
Wan Jun Poh, Cayden Pang Pee Wee, Zhiqiang Gao   +2 more
semanticscholar   +1 more source

Methylation is maintained specifically at imprinting control regions but not other DMRs associated with imprinted genes in mice bearing a mutation in the Dnmt1 intrinsically disordered domain

Frontiers in Cell and Developmental Biology, 2023
Differential methylation of imprinting control regions in mammals is essential for distinguishing the parental alleles from each other and regulating their expression accordingly.
Shaili Regmi, Lana Giha, Ahado Ali, Christine Siebels-Lindquist, Tamara L. Davis   +4 more
doaj   +1 more source

Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B [PDF]

Терапевтический архив, 2017
Aim. To define the role of DNA-methyltransferases of type 1 and type 3A in hepatitis B viral cycle. Materials and methods. Human hepatoma cells HepG2 with stable expression of 1.1-mer HBV genome were transfected with vectors encoding DNA ...
D S Kostyushev, A P Zueva, S A Brezgin, A D Lipatnikov, V N Simirskii, D Glebe, E V Volchkova, G A Shipulin, V P Chulanov   +8 more
doaj   +1 more source