Results 51 to 60 of about 259,719 (301)

Fumonisin B1 induces global DNA hypermethylation in human glioblastoma U87MG cells

Epigenetics
Fumonisin B1 (FB1) is a common maize contaminant known to induce toxicity and carcinogenesis in humans and animals; however, its epigenetic mechanisms remain poorly understood.
Ashmika Foolchand, Terisha Ghazi, Anil A. Chuturgoon   +2 more
doaj   +1 more source

Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial–mesenchymal transition and subcellular re-localization of Beta-Catenin

Epigenetics, 2020
DNA methyltransferase I plays the central role in maintenance of CpG DNA methylation patterns across the genome and alteration of CpG methylation patterns is a frequent and significant occurrence across many cancers.
Emily H Bowler, Alex Smith-Vidal, Alex Lester, Joseph Bell, Zhenghe Wang, Christopher G. Bell, Yihua Wang, Nullin Divecha, Paul J. Skipp, Rob M. Ewing   +9 more
doaj   +1 more source

Three putative DNA methyltransferases of Verticillium dahliae differentially contribute to DNA methylation that is dispensable for growth, development and virulence

Epigenetics & Chromatin, 2021
Background DNA methylation is an important epigenetic control mechanism that in many fungi is restricted to genomic regions containing transposable elements (TEs).
H. Martin Kramer, David E. Cook, Grardy C. M. van den Berg, Michael F. Seidl, Bart P. H. J. Thomma   +4 more
doaj   +1 more source

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells

Cell Death Discovery, 2022
Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2 mediated epigenetic regulation of embryonic differentiation and development is quite unknown.
Sureshkumar Perumal Srinivasan, Harshal Nemade, Anna Cherianidou, Luying Peng, Sara Cruz-Molina, Alvaro Rada-Iglesias, Agapios Sachinidis   +6 more
doaj   +1 more source

Does the catechol-O-methyltransferase (COMT) Val158Met human polymorphism in influence procrastination? [PDF]

, 2017
Genetic studies are enlightening how the expression of several genes influences neuronal activity and all facets of human normal and abnormal behaviour. Among these, a growing body of information shows that a few key genes regulating activity of central ...
Abate, Georgia, Bevilacqua, Arturo, DI NOCERA, Francesco, Ricciardi, Orlando   +3 more
core   +1 more source

DNA methyltransferases hitchhiking on chromatin

Swiss Medical Weekly, 2020
DNA methylation is an epigenetic modification that plays a central regulatory role in various biological processes. Methyl groups are coupled to cytosines by the family of DNA methyltransferases (DNMTs), where DNMT1 is the main maintenance enzyme and the DNMT3 branch of the family is mostly responsible for de novo methylation.
Baubec, Tuncay, Karemaker, Ino D
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition

Journal of Experimental & Clinical Cancer Research
Background Despite promising preclinical studies, the application of DNA methyltransferase inhibitors in treating patients with solid cancers has thus far produced only modest outcomes.
Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff   +18 more
doaj   +1 more source