Results 41 to 50 of about 2,516,689 (307)

DNA methyltransferases and their roles in tumorigenesis [PDF]

Biomarker Research, 2017
DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus ...
Zhang, Wu, Xu, Jie
openaire   +2 more sources

Crystal Structure of Human DNA Methyltransferase 1

Journal of Molecular Biology, 2015
DNA methyltransferase 1 (DNMT1) is responsible for propagating the DNA methylation patterns during DNA replication. DNMT1 contains, in addition to a C-terminal methyltransferase domain, a large N-terminal regulatory region that is comprised of an RFTS ...
Zhi-Min Zhang, Shuo Liu, Krystal Lin, Youfu Luo, J. Perry, Yinsheng Wang, Jikui Song   +6 more
semanticscholar   +1 more source

A RID-like putative cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina.

PLoS Genetics, 2019
DNA methyltransferases are ubiquitous enzymes conserved in bacteria, plants and opisthokonta. These enzymes, which methylate cytosines, are involved in numerous biological processes, notably development. In mammals and higher plants, methylation patterns
Pierre Grognet, Hélène Timpano, Florian Carlier, Jinane Aït-Benkhali, Véronique Berteaux-Lecellier, Robert Debuchy, Frédérique Bidard, Fabienne Malagnac   +7 more
doaj   +1 more source

The DNA (cytosine-5) methyltransferases [PDF]

Nucleic Acids Research, 1994
The m5C-MTases form a closely-knit family of enzymes in which common amino acid sequence motifs almost certainly translate into common structural and functional elements. These common elements are located predominantly in a single structural domain that performs the chemistry of the reaction.
Sanjay Kumar, Xiaodong Cheng, Saulius Klimasauskas, Sha Mi, Janos Posfai, Richard J. Roberts, Geoffrey G. Wilson   +6 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fumonisin B1 induces global DNA hypermethylation in human glioblastoma U87MG cells

Epigenetics
Fumonisin B1 (FB1) is a common maize contaminant known to induce toxicity and carcinogenesis in humans and animals; however, its epigenetic mechanisms remain poorly understood.
Ashmika Foolchand, Terisha Ghazi, Anil A. Chuturgoon   +2 more
doaj   +1 more source

Modulation of DNA Methyltransferase 1 Profile by γ-lrradiation Followed by Methyl Donor Starvation

Pteridines, 2005
Role of one-carbon transfer agents methyl donors namely folate, choline and methionine in DNA methylation has been the subject of extensive investigation.
Batra Vipen, Kesavan Vellappan, Mishra Kaushala P.   +2 more
doaj   +1 more source

Comparative analysis of DNA methyltransferase gene family in fungi: a focus on Basidiomycota

Frontiers in Plant Science, 2016
DNA methylation plays a crucial role in the regulation of gene expression in eukaryotes. Mushrooms belonging to the phylum Basidiomycota are highly valued for both nutritional and pharmaceutical uses.
Ruirui Huang, Qiangqiang Ding, Yanan Xiang, Tingting Gu, Yi Li, Yi Li   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)

International Journal of Oncology, 2015
O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the mismatches of O6-MG with a thymine residue during DNA replication. The dealkylating effect of
G. Cabrini, E. Fabbri, C. L. Nigro, M. Dechecchi, R. Gambari   +4 more
semanticscholar   +1 more source