Results 21 to 30 of about 2,516,689 (307)
Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases
eLife, 2023 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. The mammalian SNF2 family ATPase HELLS and its plant ortholog DDM1 are critical for maintaining 5mC. Mutations in
Hironori Funabiki +4 more
doaj +1 more source
Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers. [PDF]
PLoS ONE, 2012 Little is known about the effects of single DNA methylation events on gene transcription. The ability to direct the methylation toward a single unique site within a genome would have broad use as a tool to study the effects of specific epigenetic changes
Brian Chaikind +3 more
doaj +1 more source
Nature Communications, 2017 Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression.
Jian-Yuan Zhao +13 more
semanticscholar +1 more source
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2013 DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms.
Scarlet S Shell +6 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To explore the regulative mechanism of hypoxia/reoxygen (H/R) for invasion ability of extravillous trophoblast (EVT). Methods Immortalized human EVT cell line HTR-8/SVneo in early pregnancy, primary EVT cells isolated from the villi of placenta
HU Sichen +5 more
doaj +1 more source
DNA Methyltransferases in Depression: An Update [PDF]
Frontiers in Psychiatry, 2020 Depression is one of the most common psychiatric disorders affecting public health. Studies over the past years suggest that the methylations of some specific genes such as BDNF, SLC6A4, and NR3C1 play an important role in the development of depression.
Zhenghao Duan, Zhenghao Duan, Jie Lu
openaire +3 more sources
Tumor Biology, 2017 Promoter methylation reflects in the inactivation of different genes like O 6 -methylguanine-DNA methyltransferase DNA repair gene and runt-related transcription factor 3, a known tumor suppressor gene in various cancers such as esophageal cancer.
Snigdha Saikia +9 more
doaj +1 more source
Cell Reports, 2018 Summary: Mapping the binding sites of DNA- or chromatin-interacting proteins is essential to understanding biological processes. DNA adenine methyltransferase identification (DamID) has emerged as a comprehensive method to map genome-wide occupancy of ...
Michal Sobecki +5 more
doaj +1 more source
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
PLoS ONE, 2011 The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA ...
Tomasz P Jurkowski, Albert Jeltsch
doaj +1 more source
Genome Research, 2017 Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm.
Yi Cai +7 more
semanticscholar +1 more source