Results 11 to 20 of about 259,719 (301)
DNA methylation and DNA methyltransferases [PDF]
Epigenetics & Chromatin, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
core +9 more sources
Light‐Activation of DNA‐Methyltransferases [PDF]
Angewandte Chemie International Edition, 2021 Abstract5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis.
Jan Wolffgramm +7 more
openaire +6 more sources
Balkan Medical Journal, 2019 Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery.
Jaime A. Oliver +7 more
doaj +1 more source
Communications Biology, 2022 The methyltransferase domain of DNA methyltransferase protein 1 is an essential functional domain in acute myeloid leukemia, which is independent of DNMT3A mutation.
Balpreet Bhogal +6 more
doaj +1 more source
DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation
Annals of Medicine, 2022 DNA methylation is considered an essential epigenetic event during leukaemogenesis and the emergence of drug resistance, which is primarily regulated by DNA methyltransferases.
Mengyuan Li, Donghua Zhang
doaj +1 more source
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. [PDF]
, 2019 BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Bates, Sofie L +8 more
core +2 more sources
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]
, 2016 Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona +11 more
core +1 more source
Tumor Biology, 2017 O-6-methylguanine-DNA methyltransferase, DNA repair gene, has been found to be involved with the pathogenesis of the esophageal cancer. DNA hypermethylation and other factors have been suggested to downregulate O-6-methylguanine-DNA methyltransferase. In
Asad Ur Rehman +11 more
doaj +1 more source
Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]
, 2015 Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane +2 more
core +2 more sources
Inhibition of DNA Methyltransferase Inhibits DNA Replication [PDF]
Journal of Biological Chemistry, 2000 Ectopic expression of DNA methyltransferase transforms vertebrate cells, and inhibition of DNA methyltransferase reverses the transformed phenotype by an unknown mechanism. We tested the hypothesis that the presence of an active DNA methyltransferase is required for DNA replication in human non-small cell lung carcinoma A549 cells.
J D, Knox +6 more
openaire +2 more sources