Results 11 to 20 of about 2,516,689 (307)

Leptin DNA Methylation and Its Association with Metabolic Risk Factors in a Northwest Indian Obese Population

Journal of Obesity & Metabolic Syndrome, 2021
Background : It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines.
Sadashiv, Anupama Modi, Manoj Khokhar, Praveen Sharma, Rajnish Joshi, Sudhanshu Shekhar Mishra, Rajay N Bharshankar, Sunita Tiwari, Pankaj Kumar Singh, Vivek Vidyadhar Bhosale, Mahendra Pal Singh Negi   +10 more
doaj   +1 more source

DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension

Science Advances, 2020
DNA methyltransferase 3B is identified as a protective target against pulmonary vascular remodeling. DNA methylation plays critical roles in vascular pathology of pulmonary hypertension (PH). The underlying mechanism, however, remains undetermined. Here,
Yi Yan, Yangyang He, Xin Jiang, Yong Wang, Ji-wang Chen, Jun-Han Zhao, Jue Ye, T. Lian, Xu Zhang, Ru-Jiao Zhang, D. Lu, Shan-Shan Guo, Xi-Qi Xu, Kai Sun, Sufen Li, Lianfeng Zhang, Xue Zhang, Shu-yang Zhang, Z. Jing   +18 more
semanticscholar   +1 more source

Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity

Frontiers in Genetics, 2023
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior.
Snežana Smederevac, Lissette Delgado-Cruzata, Dušanka Mitrović, Bojana M. Dinić, Toni-Ann T. Bravo, Maria Delgado, Vojislava Bugarski Ignjatović, Selka Sadiković, Ilija Milovanović, Nataša Vučinić, Bojan Branovački, Mechthild Prinz, Zoran Budimlija, Jelena Kušić‐Tišma, Željka Nikolašević   +14 more
doaj   +1 more source

O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications

Balkan Medical Journal, 2019
Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery.
Jaime A. Oliver, Jaime Gómez-Millán, Jose A. Medina, Laura Cabeza, Gloria Perazzoli, Cristina Jimenez-Luna, Kevin Doello, Raúl Ortiz   +7 more
doaj   +1 more source

The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation

Communications Biology, 2022
The methyltransferase domain of DNA methyltransferase protein 1 is an essential functional domain in acute myeloid leukemia, which is independent of DNMT3A mutation.
Balpreet Bhogal, Barbara A. Weir, Ramona Crescenzo, Ann Marien, Min Chul Kwon, Ulrike Philippar, Glenn S. Cowley   +6 more
doaj   +1 more source

DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation

Annals of Medicine, 2022
DNA methylation is considered an essential epigenetic event during leukaemogenesis and the emergence of drug resistance, which is primarily regulated by DNA methyltransferases.
Mengyuan Li, Donghua Zhang
doaj   +1 more source

The DNA methyltransferases of mammals [PDF]

Human Molecular Genetics, 2000
The biological significance of 5-methylcytosine was in doubt for many years, but is no longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by biochemical tests to be involved in the establishment, maintenance or interpretation of genomic methylation patterns is encoded by an essential gene. A human genetic disorder (
openaire   +2 more sources

Decreased expression of MGMT in correlation with aberrant DNA methylation in esophageal cancer patients from North India

Tumor Biology, 2017
O-6-methylguanine-DNA methyltransferase, DNA repair gene, has been found to be involved with the pathogenesis of the esophageal cancer. DNA hypermethylation and other factors have been suggested to downregulate O-6-methylguanine-DNA methyltransferase. In
Asad Ur Rehman, Snigdha Saikia, Mohammad Askandar Iqbal, Istaq Ahmad, Sadaf, Afzal Anees, PS Aravinda, Pramod Kumar Mishra, Suresh Hedau, Sundeep Singh Saluja, Subhash Medhi, Syed Akhtar Husain   +11 more
doaj   +1 more source

Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

Nature Microbiology, 2019
Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated infections. Although considerable progress has been made in the understanding of its genome, the epigenome of C.
P. Oliveira, John W. Ribis, Elizabeth M. Garrett, Dominika Trzilova, Alex Kim, Ognjen Sekulovic, E. Mead, T. Pak, Shijia Zhu, G. Deikus, M. Touchon, Martha Lewis-Sandari, C. Beckford, Nathalie E. Zeitouni, D. Altman, Elizabeth Webster, I. Oussenko, S. Bunyavanich, A. Aggarwal, A. Bashir, G. Patel, F. Wallach, Camille L. Hamula, S. Huprikar, E. Schadt, R. Sebra, H. van Bakel, A. Kasarskis, R. Tamayo, A. Shen, Gang Fang   +30 more
semanticscholar   +1 more source

Cigarette smoke condensate and individual constituents modulate DNA methyltransferase expression in human liver cells

SAGE Open Medicine, 2015
Objectives: Previous studies found higher expression levels of DNA methyltransferase 1 in liver samples from smokers compared to those from non-smokers. In contrast, expression levels of DNA methyltransferase 3a and DNA methyltransferase 3b were similar ...
Yongmei Xiao, Beverly Word, Lascelles Lyn-Cook, Beverly Lyn-Cook, George Hammons   +4 more
doaj   +1 more source