Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling [PDF]
, 2008 In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1. Although silencing is regulated at the transcriptional level, it also affects transcription from other ...
Appiah, A.A. +7 more
core +3 more sources
Identification of Novel Bacterial M.SssI DNA Methyltransferase Inhibitors [PDF]
SLAS Discovery, 2013 DNA methylation is an important epigenetic regulator of gene expression. Abnormalities in DNA methylation patterns have been associated with various developmental and proliferative diseases, particularly cancer. Targeting DNA methyltransferases (DNMTs) represents a promising strategy for the treatment of such diseases.
Hupkes, M. +5 more
openaire +3 more sources
SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]
, 2015 Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei +6 more
core +2 more sources
DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
Scientific Reports, 2023 AbstractRole of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene deletion/disruption (DNMT1−/−) on anticancer activity of a class of DNMTi in vitro, in vivo and in human cancers.
Angelo B. A. Laranjeira +5 more
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Phylogeny, expression patterns and regulation of DNA Methyltransferases in early development of the flatfish, Solea senegalensis [PDF]
, 2017 Background: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish.
Armesto, Paula +5 more
core +2 more sources
Biologia Plantarum, 2019 An inhibitor of DNA methylation 5-azacytidine (5A) is a chemical analog of the nucleoside cytidine. This study investigated the influence of 5A-induced DNA hypomethylation on the accumulation of somatic DNA mutations (nucleotide substitutions, indels) in
K.V. Kiselev +4 more
doaj +1 more source
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]
, 2016 Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe +11 more
core +2 more sources
Trithorax group proteins: switching genes on and keeping them active [PDF]
, 2011 Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G. +3 more
core +1 more source
DNA methyltransferase inhibitors—state of the art
Annals of Oncology, 2002 DNA methylation is the addition of a methyl group to the 5 position of cytosine. It is an epigenetic process with several effects, including chromatin structure modulation, transcriptional repression and the suppression of transposable elements.
J, Goffin, E, Eisenhauer
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Selective Inhibitors of Bacterial DNA Adenine Methyltransferases
SLAS Discovery, 2006 The authors describe the discovery and characterization of several structural classes of small-molecule inhibitors of bacterial DNA adenine methyltransferases. These enzymes are essential for bacterial virulence (DNA adenine methyltransferase [DAM]) and cell viability (cell cycle-regulated methyltransferase [CcrM]).
Neda, Mashhoon +4 more
openaire +2 more sources