Results 271 to 280 of about 297,565 (330)

The Devil is in the details for DNA mismatch repair

Proceedings of the National Academy of Sciences of the United States of America, 2017
P. Hsieh, Yongliang Zhang
semanticscholar   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

DNA mismatch repair deficiency in conjunctival melanoma. [PDF]

Eye (Lond)
Rodriguez A, Moser J, Ramasubramanian A.
europepmc   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, EarlyView.
What's New? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer. [PDF]

Cell Rep Med
Nowak M, Jabbar F, Rodewald AK, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders M, Kerr R, Oein K, Maka N, Hay J, Edwards J, Tomlinson I, Sansom O, Kelly C, Pezzella F, Kerr D, Easton A, Domingo E, TransSCOT group, Koelzer VH, Church DN.   +22 more
europepmc   +1 more source

Novel therapeutic strategy targeting STMN1 using chlorambucil‐conjugated pyrrole–imidazole polyamide in small cell lung cancer

International Journal of Cancer, EarlyView.
What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa, Takayoshi Watanabe, Yoichi Ohtaki, Toshikazu Bando, Hiroshi Sugiyama, Takuya Araki, Hideaki Yashima, Bilguun Erkhem‐Ochir, Haruka Okami, Gendensuren Dorjkhorloo, Ikuma Shioi, Toshiteru Nagashima, Natsuko Kawatani, Tomohiro Yazawa, Eiji Narusawa, Takayuki Kosaka, Osamu Kawashima, Mitsuhiro Kamiyoshihara, John D. Minna, Luc Girard, Ken Shirabe, Hiroki Nagase, Kimihiro Shimizu, Takehiko Yokobori   +23 more
wiley   +1 more source

Co-reactivity pattern of glucose metabolism and blood perfusion revealing DNA mismatch repair deficiency based on PET/DCE-MRI in endometrial cancer. [PDF]

Cancer Imaging
Li X, Cui B, Wang S, Gao M, Xing Q, Liu H, Lu J.   +6 more
europepmc   +1 more source

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

International Journal of Cancer, EarlyView.
What's New? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M. Piskorz, Robert Brown, James D. Brenton, Iain A. McNeish, James M. Flanagan   +7 more
wiley   +1 more source

Medical Data as a Key Asset in the Digital Health Era: A Framework for Challenges and Strategies

iMetaMed, EarlyView.
By conducting case studies and comparative analysis from a global perspective, this study develops the practical framework of Medical Data Element Ecosystem (MDEE)—one that facilitates MDEE construction by guiding actions, informing policy‐making, and enabling stakeholder engagement.
Jian Wang, Anqi Lin, Yedong Huang, Gezheng Li, Tianqi Chen, Chudi Sun, Weiye Qian, Shiqi Ren, Hank Z. H. Wong, Yanxi Ding, Lin Zhang   +10 more
wiley   +1 more source

MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations. [PDF]

J Biol Chem
Kadyrova LY, Mieczkowski PA, Kadyrov FA.
europepmc   +1 more source