Results 251 to 260 of about 2,130,493 (297)
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Eukaryotic DNA mismatch repair
Current Opinion in Genetics & Development, 1999Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2-MSH3 and MSH2-MSH6. These two complexes have different mispair recognition properties and different abilities to support MMR. Alternative models have been proposed for how these MSH complexes function in MMR.
R D, Kolodner, G T, Marsischky
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Pharmacology & Therapeutics, 2018
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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DNA mismatch repair and the DNA damage response [PDF]
DNA Repair, 2016 This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on findings from mammalian cells, much has been learned from studies in other organisms including bacteria and yeast [1,2].
Zhongdao, Li +2 more
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DNA Mismatch Repair: Functions and Mechanisms
Chemical Reviews, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi R, Iyer +3 more
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Prokaryotic DNA Mismatch Repair
2006Publisher Summary There are several scientific reviews available that deal with the multitude of molecular processes involved in repairing various DNA lesions. The chapter discusses prokaryotic DNA mismatch repair pathway. Repair of base mismatches in Escherichia coli and related bacteria is performed by two molecular yet overlapping processes: the ...
Joseph, Nimesh +2 more
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DNA mismatch repair and cancer
Frontiers in Bioscience, 2003DNA mismatch repair (MMR) is an important genome caretaker system. It ensures genomic stability by correcting mismatches generated during DNA replication and recombination and by triggering apoptosis of cells with large amounts of DNA damage. Protein components responsible for these reactions are highly conserved through evolution, and homologs of ...
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DNA mismatch repair and cancer
Current Opinion in Cell Biology, 1998Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins.
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DNA Mismatch Repair and Colon Cancer
2006The Mismatch Repair (MMR) system is the major pathway responsible for repair of base-base mispairs and short insertion/deletion loops (IDLs) that arise during DNA replication and as intermediates of homologous recombination. Left unrepaired, these structures will give rise to basesubstitution and frameshift mutations, respectively.
Marra, Giancarlo, Jiricny, Josef
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Mismatch repair and DNA damage signalling
DNA Repair, 2004Postreplicative mismatch repair (MMR) increases the fidelity of DNA replication by up to three orders of magnitude, through correcting DNA polymerase errors that escaped proofreading. MMR also controls homologous recombination (HR) by aborting strand exchange between divergent DNA sequences. In recent years, MMR has also been implicated in the response
Stojic, L, Brun, R, Jiricny, J
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Targeting DNA mismatch repair for radiosensitization
Seminars in Radiation Oncology, 2001Postreplicational mismatch repair (MMR) proteins are capable of recognizing and processing not only single base-pair mismatches and insertion-deletion loops (IDLs) that occur during DNA replication, but also adducts in DNA resulting from treatment with cancer chemotherapy agents.
S E, Berry, T J, Kinsella
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