Results 231 to 240 of about 73,091 (260)
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2016
The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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DNA mismatch repair and colorectal cancer
The Journal of Pathology, 1998Colorectal cancer is the second commonest malignancy in the western world, accounting for 20,000 deaths in the U.K. per year. Over the last 10 years, great strides have been made in our understanding of the molecular controls governing the transition from normal mucosa, through adenoma, and finally to carcinoma.
N J, Toft, M J, Arends
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Eukaryotic DNA Mismatch Repair In Vitro
2012Mismatch repair corrects biosynthetic errors generated during DNA replication. Mismatch repair deficiency causes a mutator phenotype and directly underlies hereditary nonpolyposis colorectal cancer and some sporadic cancers. Because of remarkably high conservation of the mismatch repair machinery between the budding yeast (Saccharomyces cerevisiae) and
Fenghua, Yuan +4 more
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DNA Mismatch Repair in Prostate Cancer
Journal of Clinical Oncology, 2013Identification of germline mutations associated with cancer susceptibility has led to the rational development of screening protocols and prevention strategies for patients with heritable syndromes or those at increased risk for developing cancer. As reported in Journal of Clinical Oncology, Raymond et al investigated several generations of a large ...
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Molecular mechanisms of DNA mismatch repair
Mutation Research/DNA Repair, 2001DNA mismatch repair (MMR) safeguards the integrity of the genome. In its role in postreplicative repair, this repair pathway corrects base-base and insertion/deletion (I/D) mismatches that have escaped the proofreading function of replicative polymerases.
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DNA Mismatch Repair Protein Interactions on Mismatch‐Containing DNA
The FASEB Journal, 2016Lynch syndrome (LS) is the most common form of hereditary colon cancer. Stemming from the inheritance of mutations in the DNA mismatch repair (MMR) genes, LS increases lifetime risk for colonic and certain extra‐colonic cancers. Unlike sporadic cancers, LS cancers have an average age of onset of 40 years‐old.
Nilse Lene Goncalves Dos Santos +2 more
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
Cancer Cell, 2021Yong Liang +2 more
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DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer
Nature Reviews Clinical Oncology, 2010Frank Sinicrope, Sinicrope Frank A
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