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DNA mismatch repair and cancer
Current Opinion in Cell Biology, 1998Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins.
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Targeting DNA mismatch repair for radiosensitization
Seminars in Radiation Oncology, 2001Postreplicational mismatch repair (MMR) proteins are capable of recognizing and processing not only single base-pair mismatches and insertion-deletion loops (IDLs) that occur during DNA replication, but also adducts in DNA resulting from treatment with cancer chemotherapy agents.
S E, Berry, T J, Kinsella
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Mismatch repair and DNA damage signalling
DNA Repair, 2004Postreplicative mismatch repair (MMR) increases the fidelity of DNA replication by up to three orders of magnitude, through correcting DNA polymerase errors that escaped proofreading. MMR also controls homologous recombination (HR) by aborting strand exchange between divergent DNA sequences. In recent years, MMR has also been implicated in the response
Stojic, L, Brun, R, Jiricny, J
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1998
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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Constitutive deficiency in DNA mismatch repair
Clinical Genetics, 2007Mutations in the DNA mismatch repair (MMR) genes are associated with the inheritance of hereditary non‐polyposis colorectal cancer, also known as Lynch syndrome, a cancer syndrome with an average age at onset of 44. Individuals presenting with colorectal cancer are diagnosed with Lynch I, whereas individuals who present with extra‐colonic tumors (such ...
K E A, Felton +2 more
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The cell cycle and DNA mismatch repair
Experimental Cell Research, 2007The DNA mismatch repair (MMR) pathway contributes to the fidelity of DNA synthesis and recombination by correcting mispaired nucleotides and insertion/deletion loops (IDLs). We have investigated whether MMR protein expression, activity, and subcellular location are altered during discrete phases of the cell cycle in mammalian cells.
Allen G, Schroering +3 more
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Phosphorylation meets DNA mismatch repair
DNA Repair, 2018DNA mismatch repair (MMR) is a highly conserved process and ensures the removal of mispaired DNA bases and insertion-deletion loops right after replication. For this, a MutSα or MutSβ protein complex recognizes the DNA damage, MutLα nicks the erroneous strand, exonuclease 1 removes the wrong nucleotides, DNA polymerase δ refills the gap and DNA ligase ...
Isabel Madeleine Weßbecher +1 more
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DNA mismatch repair and Lynch syndrome
Journal of Molecular Histology, 2006The evolutionary conserved mismatch repair proteins correct a wide range of DNA replication errors. Their importance as guardians of genetic integrity is reflected by the tremendous decrease of replication fidelity (two to three orders of magnitude) conferred by their loss.
Guido, Plotz +2 more
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2010
The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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DNA MISMATCH REPAIR AND GENETIC INSTABILITY
Annual Review of Genetics, 2000▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability by repairing DNA replication errors, inhibiting recombination between non-identical DNA sequences and participating in responses to DNA damage. The discovery of a link between human cancer and MMR defects has led to an explosion of research on eukaryotic MMR ...
B D, Harfe, S, Jinks-Robertson
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