Results 211 to 220 of about 72,949 (261)

MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma. [PDF]

Acta Neuropathol
Friker LL, Perwein T, Waha A, Dörner E, Klein R, Blattner-Johnson M, Layer JP, Sturm D, Nussbaumer G, Kwiecien R, Spier I, Aretz S, Kerl K, Hennewig U, Rohde M, Karow A, Bluemcke I, Schmitz AK, Reinhard H, Hernáiz Driever P, Wendt S, Weiser A, Guerreiro Stücklin AS, Gerber NU, von Bueren AO, Khurana C, Jorch N, Wiese M, Kratz CP, Eyrich M, Karremann M, Herrlinger U, Hölzel M, Jones DTW, Hoffmann M, Pietsch T, Gielen GH, Kramm CM.   +37 more
europepmc   +1 more source

The ubiquitin ligase UBR4 and the deubiquitylase USP5 modulate the stability of DNA mismatch repair protein MLH1. [PDF]

J Biol Chem
Mao C, Li S, Che J, Liu D, Mao X, Rao H.
europepmc   +1 more source

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DNA mismatch repair and cancer

Mutation Research - Reviews in Mutation Research, 2001
Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
Päivi Peltomaki
exaly   +3 more sources

DNA mismatch repair: MutS structures bound to mismatches

Current Opinion in Structural Biology, 2001
When DNA mismatch repair fails, the result is a mutator phenotype, which can lead to cancer in humans. Functional repair is dependent on the recognition of mismatches by a dimeric MutS protein, a homodimer in bacteria but a heterodimer in humans. Recent crystal structures of Thermus aquaticus and Escherichia coli MutS have revealed the structural ...
Titia K Sixma
exaly   +3 more sources

Mammalian DNA Mismatch Repair

Annual Review of Genetics, 1999
▪ Abstract  DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer, S M, Deschênes, S M, Baker, R M, Liskay   +3 more
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DNA mismatch repair and cancer

Gastroenterology, 1995
The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal cancer syndromes, as well as a ...
D C, Chung, A K, Rustgi
openaire   +2 more sources

Eukaryotic DNA mismatch repair

Current Opinion in Genetics & Development, 1999
Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2-MSH3 and MSH2-MSH6. These two complexes have different mispair recognition properties and different abilities to support MMR. Alternative models have been proposed for how these MSH complexes function in MMR.
R D, Kolodner, G T, Marsischky
openaire   +2 more sources

DNA mismatch repair in cancer

Pharmacology & Therapeutics, 2018
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
openaire   +2 more sources

DNA Mismatch Repair:  Functions and Mechanisms

Chemical Reviews, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi R, Iyer, Anna, Pluciennik, Vickers, Burdett, Paul L, Modrich   +3 more
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DNA mismatch repair and cancer

Frontiers in Bioscience, 2003
DNA mismatch repair (MMR) is an important genome caretaker system. It ensures genomic stability by correcting mismatches generated during DNA replication and recombination and by triggering apoptosis of cells with large amounts of DNA damage. Protein components responsible for these reactions are highly conserved through evolution, and homologs of ...
openaire   +2 more sources