Results 191 to 200 of about 129,123 (307)

RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability. [PDF]

Nucleic Acids Res
Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML.   +14 more
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Molecular analysis of three DNA mismatch repair protein variants in Chinese families with suspected Lynch syndrome. [PDF]

Front Med (Lausanne)
Li J, Ni H, Cheng P, Peng Y, Liu L, Wang X, Cheng W, Li H, Wang X, Zhang H, Hu J, Deng A, Cai W.   +12 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Molecular and immune determinants of response in locally advanced deficient DNA mismatch repair/microsatellite instability-high gastric or gastroesophageal junction adenocarcinoma treated with neoadjuvant chemoimmunotherapy. [PDF]

Cell Commun Signal
Yu P, Huang X, Chen X, Chen H, Wang S, Wang D, Yan J, Chen J, Wei Q, Wu Z, Fang S, Chen H, Wang H, Zhu C, Huang L, Du Y, Bao H, Cheng X.   +17 more
europepmc   +1 more source

Classifying avian drinking behaviour: ecological insights and implications in a changing world

Biological Reviews, EarlyView.
ABSTRACT Water is a fundamental currency of life, and its availability significantly influences animal behaviour, physiology and distributions. However, our knowledge around the dependence on water for drinking and the direct and indirect mechanisms driving related behaviours remains partial in the context of changing climates. Here, we review patterns
Shannon R. Conradie, Marc T. Freeman
wiley   +1 more source

Real-World Impact of Metformin on Outcomes in Patients with Deficient DNA Mismatch Repair and Microsatellite Instability (dMMR/MSI) Colorectal Cancer Treated with Immune Checkpoint Inhibitors. [PDF]

Cancers (Basel)
Gupta G, Sadeghipour N, Bicer F, Elliott A, Hinton A, Lou E, Vanderwalde AM, Ozluk AA, Khushman MM, Malla M, Outlaw D, Hussaini SQ, El-Rayes BF, Akce M.   +13 more
europepmc   +1 more source

The extension of the taxon cycle model to island plants: insights from the Canarian vascular flora

Biological Reviews, EarlyView.
ABSTRACT Taxon cycle models describe eco‐evolutionary patterns of lineage colonization, diversification, and decline across archipelagos, inferring an important role for competition amongst ecologically similar taxa in driving concurrent niche changes.
José María Fernández‐Palacios, Rüdiger Otto, Robert J. Whittaker   +2 more
wiley   +1 more source

Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas. [PDF]

Asian Biomed (Res Rev News)
Eyeoğlu Ö, Kayaçetin S.
europepmc   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source