Results 171 to 180 of about 2,120,704 (297)

COMMIT: A Randomized Study of mFOLFOX6/Bevacizumab/Atezolizumab or Atezolizumab Alone as First-Line Treatment of Deficient DNA Mismatch Repair Metastatic Colorectal Cancer. [PDF]

J Clin Oncol
Rocha Lima CMSP, Yothers G, George TJ, Hochster HS, Sanoff HK, Cohen DJ, Guthrie KA, Jacobs SA, Saeed A, Kopetz S, Colangelo LH, Freeman TJ, Cole SW, Khalil M, Devanna S, Zuckerman DS, Hong TS, Henry NL, Ganz PA, Blanke CD, Wolmark N, Overman MJ.   +21 more
europepmc   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China. [PDF]

J Evid Based Med
Shi X, Yang X, Yun J, Fan X, Hou Y, Wang Z, Li P, Chen J, Jiang D, Chen L, Wang Y, Ramar R, Wong MT, Poon SL, Liang Z.   +14 more
europepmc   +1 more source

dMMR killer: A conditional suicide gene that preferentially kills DNA mismatch repair-deficient cells. [PDF]

Mol Ther Nucleic Acids
Saito S, Kato S, Arai U, Tateishi K, Adachi N.   +4 more
europepmc   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Prostate Cancer Risk and DNA Mismatch Repair Deficiency Among Lynch Syndrome Patients. [PDF]

Eur Urol Open Sci
Rodgers-Fouché L, Kamkari NA, Cruz M, Gusev A, Justiniano SI, Wu CL, Chung DC, Salari K.   +7 more
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Molecular Profiling of Germline Variants in the DNA Mismatch Repair Genes in Chinese Colorectal Cancer Patients. [PDF]

Genet Res (Camb)
Zhu X, Han D, Chen J, Xu J, Jin J, Lai Q, Xie L, Fang J, Zhu L, Yu Y, Yang J, Wang T, Xiang X, Shi X, Xiao D, Su D.   +15 more
europepmc   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Correspondence on "Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC)". [PDF]

J Cancer Res Clin Oncol
Peker P.
europepmc   +1 more source