Results 171 to 180 of about 129,123 (307)

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China. [PDF]

J Evid Based Med
Shi X, Yang X, Yun J, Fan X, Hou Y, Wang Z, Li P, Chen J, Jiang D, Chen L, Wang Y, Ramar R, Wong MT, Poon SL, Liang Z.   +14 more
europepmc   +1 more source

DNA-Mismatch-Repair [PDF]

, 2019
openaire   +1 more source

Establishment of a mouse model of propylthiouracil‐induced antineutrophil cytoplasmic antibody‐associated vasculitis

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract summarizes our study in which we established a novel murine model of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis. Neutrophil recruitment was induced using thioglycolate, followed by timed administration of propylthiouracil and phorbol 12‐myristate 13‐acetate to generate DNase I‐resistant neutrophil ...
Sakiko Masuda, Momo Uchizawa, Chihiro Terasaka, Takumi Abe, Tetsuro Nakamura, Yuka Nishibata, Yusho Ueda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu   +9 more
wiley   +1 more source

Prostate Cancer Risk and DNA Mismatch Repair Deficiency Among Lynch Syndrome Patients. [PDF]

Eur Urol Open Sci
Rodgers-Fouché L, Kamkari NA, Cruz M, Gusev A, Justiniano SI, Wu CL, Chung DC, Salari K.   +7 more
europepmc   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Efficacy of Immune Checkpoint Blockade in Advanced Upper Tract Urothelial Cancer With DNA Mismatch Repair Deficiency or Microsatellite Instability. [PDF]

JCO Precis Oncol
Moussa MJ, Andreev-Drakhlin AY, Venkatesan AM, Matin SF, Xiao L, Tidwell RSS, Shah AY, Adriazola AC, Shaw L, Gao J, Lin JK, Goswami S, Msaouel P, Guo CC, Tannir NM, Siefker-Radtke AO, Alhalabi O, Campbell MT.   +17 more
europepmc   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Correspondence on "Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC)". [PDF]

J Cancer Res Clin Oncol
Peker P.
europepmc   +1 more source

Immune checkpoint blockade in locally advanced rectal cancer with deficient DNA mismatch repair: retrospective multicenter experience. [PDF]

ESMO Open
Emiloju OE, Foster NR, Shah P, Opneja A, Gupta A, Singh M, Bonneau K, Steinert KO, Saeed A, Strickler JH, Overman MJ, Sinicrope FA.   +11 more
europepmc   +1 more source