Results 171 to 180 of about 72,949 (261)

Real-World Impact of Metformin on Outcomes in Patients with Deficient DNA Mismatch Repair and Microsatellite Instability (dMMR/MSI) Colorectal Cancer Treated with Immune Checkpoint Inhibitors. [PDF]

Cancers (Basel)
Gupta G, Sadeghipour N, Bicer F, Elliott A, Hinton A, Lou E, Vanderwalde AM, Ozluk AA, Khushman MM, Malla M, Outlaw D, Hussaini SQ, El-Rayes BF, Akce M.   +13 more
europepmc   +1 more source

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source

Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas. [PDF]

Asian Biomed (Res Rev News)
Eyeoğlu Ö, Kayaçetin S.
europepmc   +1 more source

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

iMeta, EarlyView.
This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, and prospect of large models. It aims to help researchers in the interdisciplinary field of spatial omics quickly understand the current situation and ...
Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang, Xiuhui Yang, Yutong Yang, Zirong Li, Yuqi Ren, Qianqian Zhang, Bowen Zhao, Jingming Xiao, Yidong Wang, Junhao Dong, Zhenhao Kou, Jie Li, Liqun Yang, Erhu Zhao, Gregory Fonseca, Ruibang Luo, Mingyu Yang, Hongjuan Cui, Gengjie Jia, Dan Wang, Haoyang Li, Jun Ding, Zhiyuan Yuan, Haojing Shao   +26 more
wiley   +1 more source

Genomic Alterations in DNA Mismatch Repair Genes Across Different Cancer Types. [PDF]

JCO Precis Oncol
Holla VR, Kahle MP, Kim SH, Ronaghy A, Yang RK, Patel KP, Routbort MJ, Overman MJ, Dumbrava EE, Mills Shaw KR, Karp DD, Meric-Bernstam F.   +11 more
europepmc   +1 more source

Designing chiral organic small molecules for circularly polarized light detection via group theory

InfoMat, EarlyView.
The chiral point group determines the arrangement of the μ‐m of chiral organic small molecules, thereby influencing their chiral photoelectric properties. In particular, chiral molecules with the D2 point group can effectively align the μ‐m to be either 0° or 180°, an effective strategy for high‐performance circularly polarized light photodetectors ...
Zhenping Li, Wenkai Zhao, Jiajun Fu, Wenhan Wu, Xingshuo Chu, Zihao Xu, Yu‐Wu Zhong, Hao‐Li Zhang, Wei Ma, Guankui Long, Xiaobo Shang   +10 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology. [PDF]

Trends Cancer
DeWitt JT, Raghunathan M, Haricharan S.
europepmc   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas. [PDF]

Asian Pac J Cancer Prev
Saeed NM, Rashed H, Hussein S, Al-Karamany AS, Elmesallamy W, Waley AB, Obaya AA, Gharieb SA, Amgd K, Ibrahim SM, Abdelhamid MI, Khamis T, Mohamed AH.   +12 more
europepmc   +1 more source