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DNA Mismatch Repair Protein Interactions on Mismatch‐Containing DNA
The FASEB Journal, 2016Lynch syndrome (LS) is the most common form of hereditary colon cancer. Stemming from the inheritance of mutations in the DNA mismatch repair (MMR) genes, LS increases lifetime risk for colonic and certain extra‐colonic cancers. Unlike sporadic cancers, LS cancers have an average age of onset of 40 years‐old.
Nilse Lene Goncalves Dos Santos +2 more
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Molecular mechanisms of DNA mismatch repair
Mutation Research/DNA Repair, 2001DNA mismatch repair (MMR) safeguards the integrity of the genome. In its role in postreplicative repair, this repair pathway corrects base-base and insertion/deletion (I/D) mismatches that have escaped the proofreading function of replicative polymerases.
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DNA Mismatch Repair in Prostate Cancer
Journal of Clinical Oncology, 2013Identification of germline mutations associated with cancer susceptibility has led to the rational development of screening protocols and prevention strategies for patients with heritable syndromes or those at increased risk for developing cancer. As reported in Journal of Clinical Oncology, Raymond et al investigated several generations of a large ...
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
Cancer Cell, 2021Yong liang +2 more
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DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer
Nature Reviews Clinical Oncology, 2010Frank A Sinicrope
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Differential DNA mismatch repair underlies mutation rate variation across the human genome
Nature, 2015Fran Supek, Ben Lehner
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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Nature, 2016Jiaquan Liu +2 more
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DNA Triplet Repeat Expansion and Mismatch Repair
Annual Review of Biochemistry, 2015Marek Napierala +2 more
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