Results 51 to 60 of about 70,351 (245)

Ti6Al4V‐Bioglass‐Copper Composites for Load‐Bearing Implants

Advanced Healthcare Materials, EarlyView.
We have designed and manufactured a novel Ti64‐based composite by adding 45S5 bioglass (BG) and copper (Cu). Adding BG on titanium improves wear resistance and biocompatibility, whereas Cu addition improves mechanical strength while providing inherent lifelong bacterial resistance.
Lochan Upadhayay, Bryson White, Susmita Bose, Amit Bandyopadhyay   +3 more
wiley   +1 more source

PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor

Journal of Ovarian Research, 2017
Background Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable indolent growth with malignant potential and late recurrence. Approximately 95% are of adult type. Recent molecular studies have characterized the
Wen-Chung Wang, Ya-Ting Lee, Yen-Chein Lai   +2 more
doaj   +1 more source

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, EarlyView.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Haematologica, 2018
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy.
Nikki A. Evensen, P. Pallavi Madhusoodhan, Julia Meyer, Jason Saliba, Ashfiyah Chowdhury, David J. Araten, Jacob Nersting, Teena Bhatla, Tiffaney L. Vincent, David Teachey, Stephen P. Hunger, Jun Yang, Kjeld Schmiegelow, William L. Carroll   +13 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR) w raku piersi

Menopause Review, 2010
Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers.
Hanna Romanowicz, Beata Smolarz, Tomasz Fiks, Andrzej Kulig, Ireneusz Połać, Anna Sobczuk, Tomasz Pertyński   +6 more
doaj  

A novel approach for characterizing microsatellite instability in cancer cells. [PDF]

PLoS ONE, 2013
Microsatellite instability (MSI) is characterized by the expansion or contraction of DNA repeat tracts as a consequence of DNA mismatch repair deficiency (MMRD).
Yuheng Lu, T David Soong, Olivier Elemento   +2 more
doaj   +1 more source

Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells

Advanced Materials, EarlyView.
This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur, Aljaž Kavčič, Uroš Jagodič, Rok Podlipec, Matjaž Humar   +4 more
wiley   +1 more source

DNA mismatch repair in the context of chromatin

Cell & Bioscience, 2020
DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability.
Yaping Huang, Guo-Min Li
doaj   +1 more source

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

Journal of Experimental & Clinical Cancer Research, 2023
Background Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5 ...
Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras, Isabelle Stoll, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Alfonso Bellacosa, Christian Bronner, Ali Hamiche   +10 more
doaj   +1 more source