Results 241 to 250 of about 1,176,556 (303)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Modification of DNA by chloroethylnitrosoureas.

The Japanese Journal of Veterinary Science, 1990
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

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Restriction and Modification of DNA

Annual Review of Biochemistry, 1972
RESTRICTION ENDONUCLEASES ... . Restriction endonuclease K . . . . Restriction endonuclease B ... . Restriction endonuclease P .... , . R/ and Rll restriction endonucleases, .. . Hemophilus injiuenzae endonuclease .. , .... . THE ROLES OF SAM AND ATP IN RESTRICTION, , .. SAM." ... . . . .. . . . . . . . , . ATP .. " ,.,., ... . .. , . , . . . . ..
M, Meselson, R, Yuan, J, Heywood
openaire   +2 more sources

DNA Modification and Restriction

Annual Review of Biochemistry, 1969
Publisher Summary This chapter discusses the interaction of restriction endonucleases with double-stranded DNA molecules at specific sites leading to cleavage of the DNA into a number of fragments. The specificity of this interaction is thought to depend on the recognition by the enzyme of a particular sequence of base-pairs on the substrate DNA ...
W, Arber, S, Linn
openaire   +2 more sources

Analysis of DNA modifications

Analytical and Bioanalytical Chemistry, 2005
Approximately 90% of the chemicals considered carcinogenic in humans lead, in animal experiments, either spontaneously or after metabolic activation, to covalently bound modifications of the bases of DNA, so called DNA adducts [1]. DNA adducts are the precursors of mutations, because they or their immediate neighbors are possible sites for ...
openaire   +2 more sources

Exterior modification of a DNA tetrahedron

Chemical Communications, 2010
This paper reports an introduction of extra structural features into self-assembled DNA polyhedra.
Chuan, Zhang, Min, Su, Yu, He, Yujun, Leng, Alexander E, Ribbe, Guansong, Wang, Wen, Jiang, Chengde, Mao   +7 more
openaire   +2 more sources