Results 251 to 260 of about 743,722 (313)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Modification of DNA by chloroethylnitrosoureas.

The Japanese Journal of Veterinary Science, 1990
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Methylation of DNA duplexes regulates cGAS-mediated innate immune activation <i>via</i> condensate formation. [PDF]

RSC Chem Biol
Morihiro K, Baba M, Yamada M, Okamoto A.
europepmc   +1 more source

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Restriction and Modification of DNA

Annual Review of Biochemistry, 1972
RESTRICTION ENDONUCLEASES ... . Restriction endonuclease K . . . . Restriction endonuclease B ... . Restriction endonuclease P .... , . R/ and Rll restriction endonucleases, .. . Hemophilus injiuenzae endonuclease .. , .... . THE ROLES OF SAM AND ATP IN RESTRICTION, , .. SAM." ... . . . .. . . . . . . . , . ATP .. " ,.,., ... . .. , . , . . . . ..
M, Meselson, R, Yuan, J, Heywood
openaire   +2 more sources

DNA Modification and Restriction

Annual Review of Biochemistry, 1969
Publisher Summary This chapter discusses the interaction of restriction endonucleases with double-stranded DNA molecules at specific sites leading to cleavage of the DNA into a number of fragments. The specificity of this interaction is thought to depend on the recognition by the enzyme of a particular sequence of base-pairs on the substrate DNA ...
W, Arber, S, Linn
openaire   +2 more sources

Analysis of DNA modifications

Analytical and Bioanalytical Chemistry, 2005
Approximately 90% of the chemicals considered carcinogenic in humans lead, in animal experiments, either spontaneously or after metabolic activation, to covalently bound modifications of the bases of DNA, so called DNA adducts [1]. DNA adducts are the precursors of mutations, because they or their immediate neighbors are possible sites for ...
openaire   +2 more sources

Exterior modification of a DNA tetrahedron

Chemical Communications, 2010
This paper reports an introduction of extra structural features into self-assembled DNA polyhedra.
Chuan, Zhang, Min, Su, Yu, He, Yujun, Leng, Alexander E, Ribbe, Guansong, Wang, Wen, Jiang, Chengde, Mao   +7 more
openaire   +2 more sources