Results 251 to 260 of about 1,176,556 (303)

Oxidative DNA modifications

Experimental and Toxicologic Pathology, 2005
Oxidative DNA modifications are frequent in mammalian DNA and have been suggested an important mechanism in carcinogenesis, diabetes and ageing. The foundations for this suggestion are: Evidence for the importance of oxidative DNA modifications in cancer development is: high levels of oxidative lesions in cancer tissue; highly conserved and specific ...
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DNA modification by methyltransferases

Current Opinion in Structural Biology, 1995
Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes. Structural study of the HhaI DNA methyltransferase has provided considerable insight into the chemistry of C5-cytosine methylation. The DNA-protein complex reveals a substrate cytosine flipped out of the double helix during the reaction, and a novel two-loop DNA ...
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DNA‐Modification of Eukaryotic Cells

Small, 2012
AbstractA novel bioorthogonal method for the modification of cells with single‐stranded DNA oligomers is compared to five alternative methods with respect to labeling efficacy, specificity, and effects on cell viability. The new method is based on oxime ligation of aminooxybiotin to aldehyde groups installed by periodate cleavage of cell‐surface ...
Vogel, K., Glettenberg, M., Schroeder, H., Niemeyer, C. M.   +3 more
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Catalysts for RNA and DNA modification

Current Opinion in Chemical Biology, 2015
To study DNAs and RNAs it is often necessary to chemically modify them. Nature's strategy for nucleic acid modification is to use selective catalysts, and chemists have begun to emulate this conceptual approach. In this review we present a summary of catalytic approaches toward the construction of modified RNAs and DNAs and outline our opinions on ...
Gillingham, Dennis, Shahid, Ramla
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Modifications of Circular DNA by Photoalkylation

Radiation Research, 1985
The effects of photoalkylation on superhelical PM2 DNA were examined. The chief product was 8-(2-hydroxy-2-propyl)guanine, formed exclusively in sequences of alternating purines and pyrimidines. Other purine damages included 8-(2-hydroxy-2-propyl)adenine and smaller quantities of two uncharacterized adenine products.
N J, Duker, D E, Jensen, D M, Hart
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DNA modification, differentiation, and transformation

Journal of Experimental Zoology, 1983
AbstractSubstantial evidence has accumulated over the last 5 years that the methylation of cytosine residues in vertebrate DNA is implicated in the control of gene expression. We have used analogs of cytidine, modified in the 5 position, as specific inhibitors of DNA methylation to probe the relationship between this process and cellular ...
P A, Jones, S M, Taylor, V, Wilson
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Drug Addiction and DNA Modifications

2017
Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes may underlie the causes and possibly treatment of substance use disorders.
Amber N, Brown, Jian, Feng
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“Photoclick” Postsynthetic Modification of DNA

Angewandte Chemie International Edition, 2014
AbstractA new DNA building block bearing a push–pull‐substituted diaryltetrazole linked to the 5‐position of 2′‐deoxyuridine through an aminopropynyl group was synthesized. The accordingly modified oligonucleotide allows postsynthetic labeling with a maleimide‐modified sulfo‐Cy3 dye, N‐methylmaleimide, and methylmethacrylate as dipolarophiles by ...
Stefanie, Arndt, Hans-Achim, Wagenknecht
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The recombination, repair and modification of DNA

DNA Repair, 2011
This article is an overview of the author's involvement in theoretical and experimental research on genetic recombination and DNA repair, and also on the enzymic modification of cytosine in DNA to 5-methyl cytosine. It includes the history of the discovery of the central intermediate in genetic recombination at the DNA level, and the repair of ...
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DNA Modifications and Alzheimer’s Disease

2017
Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting millions of people worldwide. While a number of studies have focused on identifying genetic variants that contribute to the development and progression of late-onset AD, the majority of these only have a relatively small effect size. There are also a number of other risk factors,
Smith, RG, Lunnon, K
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