Results 261 to 270 of about 1,176,556 (303)
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Covalent modification of DNA by daunorubicin
Cancer Chemotherapy and Pharmacology, 1993Daunorubicin, a clinically useful antitumor agent, induces mammary adenocarcinoma in Sprague-Dawley rats. As part of an investigation of the mechanism of tumor induction by daunorubicin, the formation of daunorubicin-DNA adducts has been investigated by 32P-postlabeling assay.
M, Purewal, J G, Liehr
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Chromatin Modifications in DNA Repair
2006A requirement of nuclear processes that use DNA as a substrate is the manipulation of chromatin in which the DNA is packaged. Chromatin modifications cause alterations of histones and DNA, and result in a permissive chromatin environment for these nuclear processes.
Ashby J, Morrison, Xuetong, Shen
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DNA methylation and chromatin modification
Current Opinion in Genetics & Development, 1999DNA methylation and chromatin modification are two global mechanisms that regulate gene expression. Recent studies provide insight into the mechanism of transcriptional silencing by a methyl-CpG binding protein, MeCP2. MeCP2 is shown to interact with the Sin3/histone deacetylase co-repressor complex.
H H, Ng, A, Bird
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The photodynamic modification of DNA by hematoporphyrin
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977Illumination (white light: 300-750 nm) of DNA in the presence of hematoporphyrin (less than or equal to 5-10 (-4) M) results in selective degradation of the guanine moiety. DNA so illuminated exhibits physical chemical properties (lowered sedimentation coefficients, lower temperatures of helix-coil transitions, increased buoyant density values ...
B, Gutter, W T, Speck, H S, Rosenkranz
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Reversible covalent modification of DNA
Archives of Biochemistry and Biophysics, 1974The reaction of bromomethylbenzoyl esters of choline and dimethylaminoethanol with DNA and model compounds led predominantly to phosphotriester formation. In model compounds the phosphotriester formation was verified by uv spectrometry. The bromomethylbenzoyl cationic esters reacted with DNA at room temperature at neutral pH values.
R N, Gohil, A C, Roth, R A, Day
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DNA modification by chemical carcinogens
Pharmacology & Therapeutics, 1985The chemistry and molecular biology of DNA adducts is only one part of the carcinogenic process. Many other factors will determine whether a particular chemical will exert a carcinogenic effect. For example, the size of particles upon which a carcinogenic may be adsorbed will influence whether or not, and if so where, deposition within the lung will ...
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DNA modifications in schizophrenia
2020Interplay between genetic and environmental factors plays a major role in shaping the neurodevelopmental origins of schizophrenia. Epigenetic processes act to dynamically control gene expression and are known to regulate key neurobiological and cognitive processes in the brain.
Ehsan Pishva, Bart P. F. Rutten
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Assessment of DNA Epigenetic Modifications
Chemical Research in Toxicology, 2019DNA molecules utilize adenine, thymine, cytosine, and guanine for coding genetic information. In addition to these four canonical nucleobases, DNA molecules also contain a variety of modified nucleobases that can control and regulate gene expression and chromosome structure.
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Cytometry of DNA mutation and modification
Cytometry Part A, 2009MORE than 100 years after the discovery of chromosomes, new techniques for their investigation are still being developed and the knowledge obtained about their structure and function continues to grow. Comparative genomic hybridization (CGH) allows the analysis of genomic instability at the chromosomal level (by 10 Mbp resolution).
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