Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing [PDF]
Biology Direct, 2013 BACKGROUND: The major role of enzymatic toxins that target nucleic acids in biological conflicts at all levels has become increasingly apparent thanks in large part to the advances of comparative genomics.
A Maxwell Burroughs +4 more
core +2 more sources
Biological Activity of the phenylethanol and its derivatives. Influence on isolated DNA nucleotidyltransferase and DNAase [PDF]
FEBS Letters, 1970 Müller, W.E.G. +4 more
openaire +4 more sources
[Terminal DNA nucleotidyltransferase in blastic crisis in myelocytic leukemia].
Acta haematologica Polonica, 1982 The importance of determination of the activity of TdT is discussed in the light of a case of chronic myeloid leukaemia in a patient aged 55 years in whom after 4 years from the onset of the disease blastic crisis developed. High TdT activity was correlated with other features of blastic crisis of lymphoid character and with good response to ...
E, Rudzka +4 more
openaire +2 more sources
Comparative Genomics of Lactococcus spp. From Global Aquaculture Outbreaks Reveals Virulence Determinants, Antibiotic Resistance, and Phage Defence Mechanisms. [PDF]
MicrobiologyopenLactococcus petauri predominated in isolates from outbreaks of lactococcosis, suggesting a shift in disease aetiology. Genomic analysis revealed diverse virulence factors, prophage and resistance genes, while antimicrobial susceptibility testing showed uniform resistance to common antibiotics found in farming systems, emphasising the need for ...
Blanchard AM +9 more
europepmc +2 more sources
The Role and Therapeutic Potential of the cGAS-STING Signaling Pathway in Alzheimer's Disease. [PDF]
Brain BehavThis work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Li X, Gao W, Ye Q, Li H.
europepmc +2 more sources
Signal Transduction and Targeted Therapy, 2023 In their recently published study in Nature , Jenson et al. 1 provide compelling, unexpected evidence that bacterial cGAMP synthase (cGAS) and other cGAS/DncV-like Nucleotidyltransferases (CD-NTase) undergo ubiquitin-like conjugation (ULC) in type-II ...
Katarzyna Andryka-Cegielski +2 more
semanticscholar +1 more source
cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette
Faculty Reviews, 2021 Stimulator of interferon genes (STING) functions in the cytosolic DNA-sensing pathway of innate immunity in mammals. It is activated upon binding the cyclic dinucleotide 2′3′-cGAMP, a second messenger produced by the enzyme cyclic guanosine monophosphate–
Hua Cai, J. Imler
semanticscholar +1 more source
A eubacterial origin for the human tRNA nucleotidyltransferase? [PDF]
, 2001 tRNA CCA-termini are generated and maintained by tRNA nucleotidyltransferases. Together with poly(A) polymerases and other enzymes they belong to the nucleotidyltransferase superfamily.
Aebi M. +12 more
core +1 more source
Sequence motifs that distinguish ATP(CTP) : tRNA nucleotidyl transferases from eubacterial poly(A) polymerases [PDF]
, 2004 ATP(CTP):tRNA nucleotidyl transferases, tRNA maturing enzymes found in all organisms, and eubacterial poly(A) polymerases, enzymes involved in mRNA degradation, are so similar that until now their biochemical functions could not be distinguished by their
Keller, W., Martin, G.
core +2 more sources
Nucleic Acids Research, 2015 Many dsDNA viruses encode DNA-packaging terminases, each containing a nuclease domain that resolves concatemeric DNA into genome-length units. Terminase nucleases resemble the RNase H-superfamily nucleotidyltransferases in folds, and share a two-metal ...
Haiyan Zhao +7 more
semanticscholar +1 more source