Results 51 to 60 of about 2,027,606 (189)

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei, Kui Zhao, Yifan Wu, Wenhui Wu, Na Hao   +4 more
wiley   +1 more source

Unusual tRNA nucleotidyltransferases: Adaptation of the Romanomermis culicivorax CCA-adding enzyme towards armless tRNAs and characterization of the phosphodiesterase domain of the Escherichia coli CCA-adding enzyme [PDF]

, 2022
tRNAs spielen eine zentrale Rolle in jedem bekannten Organismus. Sie agieren als Adaptoren, um den Code der Nukleinsäuren in eine funktionale Aminosäuresequenz zu übersetzen.
Philipp, Susanne
core   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Infrared Spectroscopy Coupled with a Dispersion Model for Quantifying the Real-Time Dynamics of Kanamycin Resistance in Artificial Microbiota [PDF]

, 2017
Overusage of antibiotics leads to the widespread induction of antibiotic-resistance genes (ARGs). Developing an approach to allow real-time monitoring and fast prediction of ARGs dynamics in clinical or environmental samples has become an urgent matter ...
Jin, Naifu, Martin, Francis L, Paraskevaidi, Maria, Semple, Kirk T., Zhang, Dayi   +4 more
core   +2 more sources

Discovery of Three Toxic Proteins of Klebsiella Phage fHe-Kpn01 [PDF]

, 2020
The lytic phage, fHe-Kpn01 was isolated from sewage water using an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae as a host. The genome is 43,329 bp in size and contains direct terminal repeats of 222 bp.
Pajunen, Maria I., Skurnik, Mikael, Spruit, Cindy M., Wan, Xing, Wicklund, Anu   +4 more
core   +3 more sources

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the african trypanosome [PDF]

, 2013
Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication.
Aguilera, Aidan J. Doherty, Alsford, Altschul, Brun, Burton, Bétous, Callegari, Callegari, Daigaku, David Horn, Della, di Caprio, Diamant, El-Sayed, Elvers, Frick, Garg, Glover, Glover, Godoy, Heller, Hines, Hines, Hopfner, Iyer, Jansen, Jansen, Jozwiakowski, Karras, Kuchta, Lange, Lao-Sirieix, Lazzaro, Lehmann, Li, Lopes, Lucy Glover, Muzi-Falconi, Passos-Silva, Pitcher, Plosky, Proudfoot, Rastogi, Rey, Rupp, Sale, Sean G. Rudd, Siegel, Stanislaw K. Jozwiakowski, Tiengwe, Tiengwe, Ulrich, van Luenen, Waters, Waters, Woodward   +56 more
core   +4 more sources

Antimicrobial Susceptibility Profile of Escherichia coli Isolates From Artisanal Colonial Cheese in Southern Brazil

Food Safety and Health, Volume 3, Issue 4, Page 659-667, October 2025.
This study evaluated the antimicrobial susceptibility profile of Escherichia coli isolated from artisanal colonial cheese from Brazil. Sixty percent of the isolates showed resistance to at least one antimicrobial, no ESBL was found, genes blaTEM and tetB were found simultaneously in four isolates.
Luísa Aimée Schmitt Lobe, Vanessa Cortina Zanetti, Natália Regina Coldebella Ferreira, Matheus Viapiana Frutuoso, Isadora Caroline Marian, Emanueli Marchesan Maran, Manuela Maggiora Freitas Bastos, Julia Eduarda Munaretto, Gustavo Rocha, Mateus Rocha Ribas, Victor Felipe Wolleck, Francisco Lucas Amorim Nascimento, Jussara Kasuko Palmeiro, Marília Miotto‐Lindner, Silvani Verruck   +14 more
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source