Results 201 to 210 of about 954,914 (266)

Recognition of unnatural base pairs by a eukaryotic DNA polymerase enables universal sequencing of an expanded genetic alphabet. [PDF]

Nucleic Acids Res
Luo H, Du Y, Sun L, Ye F, Ma J, Wang X, Wang Y, Chen T.   +7 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Universal Regulation of DNA Polymerase via Photocaged Primer Enables Light-Start Isothermal Amplification on Demand. [PDF]

Adv Sci (Weinh)
Qing M, Qin Y, Li Z, Yu X, Wang J, Liu X, Chen X, Yu C.   +7 more
europepmc   +1 more source

Understanding the Catalytic Determinant role of Diaphorase‐Like Subunit in Formate Dehydrogenases via Redox Couples

Advanced Science, EarlyView.
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang, Weisong Liu, Hao Su, Huijuan Cui, Yuanming Wang, Zhiguang Zhu, Chun You, Lingling Zhang   +7 more
wiley   +1 more source

Binding of SARS-CoV-1/2 NSP1 to DNA Polymerase α-Primase Inhibits DNA Replication through Reduction of Interaction between DNA and DNA Polymerase α-Primase. [PDF]

J Chem Inf Model
Nguyen HV, Ngoc Lan NL, Li MS.
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs. [PDF]

Nucleic Acids Res
van der Sluijs RV, Verkennis AEE, Hodskinson MR, Barnett J, Cruz VM, Hernandez-Quiles M, Liolios T, Morton SB, Hendrikx A, Bos C, Post H, Millington CL, Rouillon C, Ricci G, Mattiroli F, Williams DM, Altelaar M, Vermeulen M, Patel KJ, Knipscheer P.   +19 more
europepmc   +1 more source

A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens. [PDF]

Nat Commun
Urem M, Friggen AH, Musch N, Silverman MH, Swain CJ, Barbachyn MR, Mortin LI, Yu X, DeLuccia RJ, Lamers MH, Smits WK.   +10 more
europepmc   +1 more source

Human TLS DNA polymerase: saviors or threats under replication stress? [PDF]

Mol Cell Biochem
Rajpurohit YS, Lal M, Sharma DK, Soni I.
europepmc   +1 more source