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[8] Purification of mammalian DNA polymerases: DNA polymerase α
1995Publisher Summary This chapter discusses the purification of mammalian DNA polymerases, DNA polymerase α. DNA polymerase α plays a key role in the initiation and replication of the mammalian chromosome. The production of a panel of monoclonal antibodies against human DNA polymerase α allowed the development of a three-step immunoaffinity purification
Lars Rogge +3 more
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Current Protocols in Molecular Biology, 2012
AbstractThe DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database. Curr. Protoc. Mol. Biol. 99:3.25.1‐3.25.2. © 2012 by John Wiley & Sons, Inc.
Nicole M. Nichols, Bradley W. Langhorst
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AbstractThe DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database. Curr. Protoc. Mol. Biol. 99:3.25.1‐3.25.2. © 2012 by John Wiley & Sons, Inc.
Nicole M. Nichols, Bradley W. Langhorst
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2012
DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis.
Erik Johansson, Matthew Hogg
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DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis.
Erik Johansson, Matthew Hogg
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Biochemical and Biophysical Research Communications, 1965
Abstract An experiment will be described which shows that DNA polymerase helps select the base in DNA replication. After elucidating the structure of DNA (1953a), Watson and Crick proposed a template mechanism for the replication of DNA (1953b).
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Abstract An experiment will be described which shows that DNA polymerase helps select the base in DNA replication. After elucidating the structure of DNA (1953a), Watson and Crick proposed a template mechanism for the replication of DNA (1953b).
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2004
Publisher Summary This chapter focuses on DNA polymerases (Pols) and their functions. DNA Pols are central players in DNA repair and replication—the processes that duplicate genomes and maintain their integrity to ensure faithful transmission of genetic information from one generation to other.
Thomas A. Kunkel, Katarzyna Bebenek
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Publisher Summary This chapter focuses on DNA polymerases (Pols) and their functions. DNA Pols are central players in DNA repair and replication—the processes that duplicate genomes and maintain their integrity to ensure faithful transmission of genetic information from one generation to other.
Thomas A. Kunkel, Katarzyna Bebenek
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1996
Publisher Summary This chapter describes DNA polymerases of mesophiles and covers DNA polymerases of thermophilic Eubacteria and Archaea. It covers both thermophiles, organisms that grow optimally in the range of 50–70oC, but not at 90oC, and hyperthermophiles, organisms with an optimal growth temperature of at least 80°C, which also grow at 90°C ...
Huimin Kong +2 more
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Publisher Summary This chapter describes DNA polymerases of mesophiles and covers DNA polymerases of thermophilic Eubacteria and Archaea. It covers both thermophiles, organisms that grow optimally in the range of 50–70oC, but not at 90oC, and hyperthermophiles, organisms with an optimal growth temperature of at least 80°C, which also grow at 90°C ...
Huimin Kong +2 more
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Nature, 1968
EVIDENCE which has accumulated over the past decade from mammalian and non-mammalian sources about the enzyme(s) involved in DNA synthesis has indicated the possibility of a multiunit structure for this enzyme. Mammalian DNA polymerase DNA nucleotidyl-transferase (E.G.2.7.7.7) was first isolated from a high speed supernatant fraction of cell ...
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EVIDENCE which has accumulated over the past decade from mammalian and non-mammalian sources about the enzyme(s) involved in DNA synthesis has indicated the possibility of a multiunit structure for this enzyme. Mammalian DNA polymerase DNA nucleotidyl-transferase (E.G.2.7.7.7) was first isolated from a high speed supernatant fraction of cell ...
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1975
Publisher Summary This chapter states that physiological experiments demonstrating variations of DNA polymerase activities were first done in mammalian systems, whereas the first relevant genetic experiments in bacteria came 12 years after the discovery of Escherichia coli DNA polymerase I.
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Publisher Summary This chapter states that physiological experiments demonstrating variations of DNA polymerase activities were first done in mammalian systems, whereas the first relevant genetic experiments in bacteria came 12 years after the discovery of Escherichia coli DNA polymerase I.
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Chemical Reviews, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Mammalian DNA Helicases, DNA Polymerases and DNA Polymerase Auxiliary Proteins
1993DNA replication must guarantee the faithful duplication of the genetic information in advance of cell division. Research progress in the last few years suggested that mechanisms of DNA replication might be similar in most organisms investigated so far (Kornberg and Baker 1992).
Ulrich Hübscher +9 more
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