Results 241 to 250 of about 1,030,716 (269)

Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple Negative Breast Cancer. [PDF]

Cancer Res
Sher EF, Fujihara KM, Tao A, Sastourne-Haletou P, Erenburg D, Sviderskiy VO, Mir H, Karakousi T, Loomis CA, Deng J, Ruggles KV, Wong KK, Possemato R.   +12 more
europepmc   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs. [PDF]

Nucleic Acids Res
van der Sluijs RV, Verkennis AEE, Hodskinson MR, Barnett J, Cruz VM, Hernandez-Quiles M, Liolios T, Morton SB, Hendrikx A, Bos C, Post H, Millington CL, Rouillon C, Ricci G, Mattiroli F, Williams DM, Altelaar M, Vermeulen M, Patel KJ, Knipscheer P.   +19 more
europepmc   +1 more source

A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens. [PDF]

Nat Commun
Urem M, Friggen AH, Musch N, Silverman MH, Swain CJ, Barbachyn MR, Mortin LI, Yu X, DeLuccia RJ, Lamers MH, Smits WK.   +10 more
europepmc   +1 more source

The S180R Human Germline Variant of DNA Polymerase β Is a Low Fidelity Enzyme with Reduced Flexibility of the Fingers Domain. [PDF]

Biochemistry
Sawyer DL, Eckenroth BE, Chavira C, Alnajjar K, Hanley JP, Dragon JA, Doublié S, Sweasy JB.   +7 more
europepmc   +1 more source

Discovery of <b>RP-37</b> analogues as potent, selective irreversible inhibitors targeting DNA polymerase theta (POLθ). [PDF]

RSC Med Chem
Wang Z, Qiu M, Liu D, Yu Y, Gu D, Zhang F, Sheng R.   +6 more
europepmc   +1 more source

Correction for Tian et al., DNA polymerase delta governs parental histone transfer to DNA replication lagging strand. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

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RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination

Cell, 2021
Sijie Liu, Junjie Yuan, Ziyang Wang
exaly