Results 41 to 50 of about 542,507 (360)

Identification of the Kna/Knb polymorphism and a method for Knops genotyping [PDF]

, 2004
BACKGROUND: DNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)—a ligand for rosetting of Plasmodium falciparum-infected RBCs.
Daniels, Helgeson, Krych-Goldberg, Mallan, Molthan, Molthan, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Moulds, Rao, Rowe, Tamasauskas, Zimmerman   +17 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Organellar inheritance in the green lineage: insights from Ostreococcus tauri [PDF]

, 2013
Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain.
Adam Eyre-Walker, Baur, Birky, Bonen, Boynton, Bruen, Correns, De Clerck, Derelle, Duret, Grimsley, Guindon, Gwenael Piganeau, Hasegawa, Hill, Hill, Houliston, Hua, Huang, Hurst, Hutson, Jancek, Kurtz, Larkin, Lewis, Lewontin, Li, MacAlpine, Marin, Marshall, Maréchal, Maynard Smith, McVean, Miyamura, Muller, Nei, Ness, Olson, Piganeau, Posada, Posada, R Development Core Team, Robbens, Rodríguez-Ezpeleta, Romain Blanc-Mathieu, Sager, Sager, Sager, Simpson, Sophie Sanchez-Ferandin, Städler, Sun, Sung, Swofford, Tamura, Tamura, Tsai   +56 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease

Blood Pressure, 2017
Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report
Marcin Wirtwein, Olle Melander, Marketa Sjőgren, Michal Hoffmann, Krzysztof Narkiewicz, Marcin Gruchala, Wojciech Sobiczewski   +6 more
doaj   +1 more source

Analysis of the chalcone synthase from Humulus lupulus L. and biotechnology aspects of medicinal hops

Plant, Soil and Environment, 2002
The complete sequence hop gene, which corresponds to true chalcone synthase (EC 2.3.1.74), was amplified using a combination of PCR, RT PCR and inverse PCR methods and cloned from Czech Osvald's clone 72.
J. Matoušek, P. Novák, J. Patzak, J. Bříza, K. Krofta   +4 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Promoter Hypermethylation of Wnt/β-catenin Signaling Pathway Inhibitor WIF-1 Gene and its Association with MTHFR C677T Polymorphism in Patients with Colorectal Cancer

Oman Medical Journal, 2020
Objectives: Colorectal cancer (CRC) is a common malignancy with a high rate of mortality. The dysregulation of genes involved in the Wnt/β-catenin signaling pathway is a common finding in cancers.
Ahmad Jalilvand, Mohammad Soleiman Soltanpour   +1 more
doaj   +1 more source

A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes [PDF]

, 2008
A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^.
Duš, Iveta Waczulí, Já, Jozef Hatok, Monika Sivoň, Peter Rač, Tatiana Matá   +6 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source