Results 51 to 60 of about 1,931,156 (311)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

DNA methylation patterns in cord blood DNA and body size in childhood. [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND ...
Pearce, M., Mark S. Pearce (177539), Ness, Andy R, Caroline L Relton, St Pourcain, B., Joseph Trakalo (177545), Shaheen Seif O., Embleton, N., Swan, DC, Ness, AR, George Davey Smith (82619), Seif O. Shaheen (177559), Shaheen, S., Relton, Caroline L, Ring, SM, Relton, C., Jon H Tobias, Swan, D., Sayers, AE, Alexandra Groom, Caroline L. Relton (174120), Susan M. Ring (116089), Embleton Nicholas D., Alexandra Groom (174101), Andy R Ness, Andy R. Ness (177551), Ring Susan M., Beate St. Pourcain (152905), Sayers, Adrian E, Tobias Jon H., Ness Andy R., Trakalo, J, St Pourcain, B, Sayers Adrian E., Groom, A., Tobias, Jonathan H, Relton Caroline L., St. Pourcain Beate, St Pourcain, M U B, Nicholas D Embleton, Tobias, J., Jon H. Tobias (153172), Northstone, K., Beate St Pourcain, Northstone, K, Davey Smith George, Trakalo Joseph, Groom Alexandra, Joseph Trakalo, Sayers, A., Kate Northstone (74777), Tobias, JH, Davey Smith, George, Groom, A, Ring, Susan M, Davey Smith, G, Pearce, MS, Northstone, Kate, Nicholas D. Embleton (177535), Susan M Ring, Pearce Mark S., Daniel C Swan, Ness, A., Swan Daniel C., Mark S Pearce, Northstone Kate, Relton, CL, Adrian E Sayers, Shaheen, SO, George Davey Smith, Trakalo, J., Adrian E. Sayers (177532), Embleton, ND, Davey Smith, G., Kate Northstone, Seif O Shaheen, Ring, S., Daniel C. Swan (124594)   +77 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genetic stability among in vitro eggplant clones induced by different plant growth regulators

Biotecnología Vegetal, 2019
Many factors may influence the genetic stability of plant in vitro clones, among which the genotype and the regenerative process induced by plant growth regulators.
Ana Paula Mançano, Bianka de Oliveira Soares , Renata de Oliveira Garcia, Elisabeth Atalla Mansur, Rachel Fatima Gagliardi   +4 more
doaj  

Genetic variability of Nero Lucano pig breed at IGF2, LEP, MC4R, PIK3C3, RYR1 and VRTN loci

Italian Journal of Animal Science, 2019
The Nero Lucano pig is a native breed of Southern Italy which thanks to the joint action of Basilicata Region Institutions, University of Basilicata and breeders returned to populate the area of origin.
Carmelisa Valluzzi, Andrea Rando, Paola Di Gregorio   +2 more
doaj   +1 more source

Advances in plant gene-targeted and functional markers: a review [PDF]

, 2013
Public genomic databases have provided new directions for molecular marker development and initiated a shift in the types of PCR-based techniques commonly used in plant science.
Ildikó Varga, Poczai, Péter, Neil Bell, Hyvönen Jaakko, Valkonen, Jari PT, Maarja Laos, Hyvönen, Jaakko, Cseh, András, Varga Ildikó, Varga, Ildikó, Laos, Maarja, Cseh András, Bell Neil, Poczai Péter, Valkonen, Jari, Cseh, András Attila, Péter Poczai, Jari PT Valkonen, Valkonen Jari PT, Jaakko Hyvönen, Bell, Neil, András Cseh, Laos Maarja   +22 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Use of AFLP and PFGE to discriminate between Salmonella enterica serovar Typhimurium DT126 isolates from separate food-related outbreaks in Australia [PDF]

, 2005
In 2001 Salmonella enterica serovar Typhimurium definitive phage-type (DT) 126 was isolated at higher frequency in Australia compared to other S. Typhimurium phage types and in comparison to previous years.
Heuzenroeder, M., Ross, I.
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Factors affecting HBV DNA suppression in chronic hepatitis B patients treated with tenofovir disoproxil fumarate [version 2; peer review: 2 approved]

F1000Research, 2023
Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 to August 2022 on 182 chronic hepatitis
Putri Chairani Eyanoer, Masrul Lubis, Mustafa Mahmud Amin, Fauzi Yusuf, Tri Widyawati, Muhammad Rusda, Dharma Lindarto, Jelita Siregar, Imelda Rey, Darmadi Darmadi   +9 more
doaj   +1 more source