Results 111 to 120 of about 4,042,809 (333)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A mutate-and-map protocol for inferring base pairs in structured RNA

, 2013
Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling.
CS Chow, D Moazed, DH Mathews, EE Regulski, JB Lucks, JG Underwood, JP Staley, KA Wilkinson, M Kertesz, M Mandal, N Kulshina, NB Leontis, P Cordero, P Cordero, P Rocca-Serra, P Tijerina, PJ Lukavsky, R Rydzanicz, RC Spitale, RF Gesteland, S Mitra, S Washietl, S Yoon, SA Mortimer, SE Wells, SM Vasa, SW Brostoff, VD Sood, W Kladwang, W Kladwang, W Kladwang, W Kladwang, Y Rhee   +32 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Comparison of Two Multiplex PCR Systems for Meat Species Authentication

Journal of Food Quality and Hazards Control, 2019
Background: Meat species adulteration has become a problem of concern. This study aimed to compare two previously published multiplex Polymerase Chain Reaction (PCR) methods for meat species authentication.
D. Al-taghlubee, A. Misaghi, P. Shayan, A. Akhondzadeh Basti, H. Gandomi, D. Shayan   +5 more
doaj  

SELEÇÃO DE MARCADORES ISSR PARA Schizolobium parahyba var. amazonicum (Huber ex. Ducke) Barneby

Revista UniVap, 2017
O objetivo deste trabalho foi selecionar primers ISSR para serem utilizados em futuras análises de diversidade genética em população de S. amazonicum, conhecido popularmente como Paricá.
Adelson Lemes da Silva Júnior, Lucimara Cruz de Souza, Aléxia Gonçalves Pereira, Kelmer Mozer Moro, Mariana Cruz de Souza, Alessandra Abreu Rodrigues, Izabela Ferreira Ribeiro, Fábio Demolinari de Miranda, Marcos Vinicus Winckler Caldeira   +8 more
doaj   +1 more source

Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]

, 2013
• Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core  

Identification of nodule-dominant Rhizobium meliloti strains carrying pRmeGR4b-type plasmid within indigenous soil populations by PCR using primers derived from specific DNA sequences [PDF]

, 1995
Pablo J. Villadas, Encarna Velázquez, Eustoquio Martı́nez-Molina, Nicolás Toro   +3 more
openalex   +1 more source

Adapterama I: universal stubs and primers for 384 unique dual-indexed or 147,456 combinatorially-indexed Illumina libraries (iTru & iNext)

PeerJ, 2019
Massively parallel DNA sequencing offers many benefits, but major inhibitory cost factors include: (1) start-up (i.e., purchasing initial reagents and equipment); (2) buy-in (i.e., getting the smallest possible amount of data from a run); and (3) sample ...
T. Glenn, R. Nilsen, Troy J. Kieran, J. Sanders, N. Bayona‐Vásquez, J. W. Finger, Todd W. Pierson, K. Bentley, Sandra L. Hoffberg, Swarnali Louha, F. J. García-De León, Miguel Angel del Rio Portilla, K. Reed, Jennifer L. Anderson, J. Meece, S. Aggrey, R. Rekaya, Magdy S. Alabady, Myriam Bélanger, K. Winker, B. Faircloth   +20 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

SELEÇÃO DE PRIMERS ISSR PARA ANÁLISES DE DIVERSIDADE GENÉTICA EM Plathymenia reticulata Benth

Revista UniVap, 2017
O objetivo deste trabalho foi selecionar primers ISSR para serem utilizados em futuras análises de diversidade genética em populações naturais de P. reticulata. Amostras foliares de cinco indivíduos da espécie foram coletadas para extração e purificação
Lucimara Cruz de Souza, Adelson Lemes da Silva Júnior, Aléxia Gonçalves Pereira, Mariana Cruz de Souza, Kelmer Mozer Moro, Alessandra Abreu Rodrigues Vieira, Izabela Ferreira Ribeiro, Sustanis Horn Kunz, Fábio Demolinari de Miranda   +8 more
doaj   +1 more source