Results 61 to 70 of about 3,903,497 (411)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Comparison of different primes for PCR-based diagnosis of cutaneous leishmaniasis

Brazilian Journal of Infectious Diseases
OBJECTIVE: The objective of this study was to analyze different primers that are commonly used in epidemiological studies for the detection of Leishmania DNA by PCR, and to compare them to the conventional direct parasite search for American cutaneous ...
Diego Molina de Oliveira, Maria Valdrinez Campana Lonardoni, Ueslei Teodoro, Thais Gomes Verzignassi Silveira   +3 more
doaj   +1 more source

Single molecule techniques in DNA repair: A primer [PDF]

DNA Repair, 2014
A powerful new approach has become much more widespread and offers insights into aspects of DNA repair unattainable with billions of molecules. Single molecule techniques can be used to image, manipulate or characterize the action of a single repair protein on a single strand of DNA.
Hughes, Craig D, Simons, Michelle, Mackenzie, Cassidy E, Van Houten, Bennett, Kad, Neil M   +4 more
openaire   +4 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Pilot progress in DNA isolation and amplification from the material stored at the LWS herbarium

Інтродукція Рослин
The isolation of DNA from the herbarium specimens deposited at the LWS herbarium (State Museum of Natural History of the NAS of Ukraine, Lviv, Ukraine) has been tested using the column-based protocol.
Andriy Novikov, Viktor Nachychko
doaj   +1 more source

Blocking primers to enhance PCR amplification of rare sequences in mixed samples – a case study on prey DNA in Antarctic krill stomachs

Frontiers in Zoology, 2008
Background Identification of DNA sequence diversity is a powerful means for assessing the species present in environmental samples. The most common molecular strategies for estimating taxonomic composition depend upon PCR with universal primers that ...
Jarman Simon N, Vestheim Hege
doaj   +1 more source

Intra- and interspecific polymorphisms ofLeishmania donovani andL. tropica minicircle DNA [PDF]

, 1994
A pair of degenerate polymerase chain reaction (PCR) primers (LEI-1, TCG GAT CC[C,T] [G,C]TG GGT AGG GGC GT; LEI-2, ACG GAT CC[G,C] [G,C][A,C]C TAT [A,T]TT ACA CC) defining a 0.15-kb segment ofLeishmania minicircle DNA was constructed.
AJ Magill, DC Barker, DF Smith, DG Higgins, F Sanger, GZ Kidane, H. Rinder, JM Blackwell, K Stuart, MHL Bruijn de, P. Dobner, R Sommer, RD Kreutzer, S Lee, T Laskay, T. L�scher, WO Rogers   +16 more
core   +1 more source

Self-reporting PNA/DNA primers for PCR analysis.

Genome Research, 2001
We report a new fluorogenic method for sealed-tube PCR analysis using a quencher-labeled peptide nucleic acid (Q-PNA) probe. The Q-PNA hybridizes to a complementary tag sequence located at the 5' end of a 5' fluorophore-labeled oligonucleotide primer ...
M. Fiandaca, J. J. Hyldig-Nielsen, B. Gildea, J. Coull   +3 more
semanticscholar   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Fungal-specific PCR primers developed for analysis of the ITS region of environmental DNA extracts

BMC Microbiology, 2005
Background The Internal Transcribed Spacer (ITS) regions of fungal ribosomal DNA (rDNA) are highly variable sequences of great importance in distinguishing fungal species by PCR analysis.
Rygiewicz Paul T, Martin Kendall J
doaj   +1 more source