Results 41 to 50 of about 1,480,527 (305)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

DNA Probes and Primers in Dental Practice [PDF]

Clinical Infectious Diseases, 2002
In clinical microbiology, molecular genetic techniques are increasingly being used to detect and/or differentiate uncultivable, anaerobic, or fastidious microorganisms. During the past decade, DNA probe hybridization and in vitro amplification by polymerase chain reaction have also been introduced to detect oral pathogens.
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Detection of herpes simplex virus 2: a SYBR-Green-based real-time PCR assay [version 2; peer review: 2 approved]

F1000Research, 2021
The prevalence of Herpes simplex virus 2 (HSV2) is increasing at an alarming rate in the world. Most of the HSV2 cases are not diagnosed properly, although a range of molecular and serological diagnoses exist.
Modhusudon Shaha, Mohammad Ariful Islam, Bithi Roy   +2 more
doaj   +1 more source

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]

, 2015
Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty, Benjamin A. Keen, Bianchi, Bouché, Collins, Crute, Kaguni, Klinedinst, Klinedinst, Koonin, Marsden, Moss, Nigel C. Brissett, Rowen, Scherzinger, Sherman, Takechi, Thomas A. Guilliam   +17 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pilot progress in DNA isolation and amplification from the material stored at the LWS herbarium

Інтродукція Рослин
The isolation of DNA from the herbarium specimens deposited at the LWS herbarium (State Museum of Natural History of the NAS of Ukraine, Lviv, Ukraine) has been tested using the column-based protocol.
Andriy Novikov, Viktor Nachychko
doaj   +1 more source

SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae [PDF]

, 2011
Segregation of replicated chromosomes is an essential process in all organisms. How bacteria, such as the oval-shaped human pathogen Streptococcus pneumoniae, efficiently segregate their chromosomes is poorly understood.
Avery, Baerends, Bloom, Bouthier de la Tour, Britton, Dagkessamanskaia, Danilova, Eberhardt, Errington, Fadda, Ferrandiz, Fogel, Gasc, Gerdes, Glaser, Graumann, Gruber, Guthlein, Halfmann, Hendriksen, Hoskins, Hudson, Hui, Ireton, Jun, Jun, Katayama, Kloosterman, Kornberg, Lanie, Leenhouts, Lin, Lindow, Livny, Lynch, Martin, Mascarenhas, Mitchell, Moriya, Mott, Murray, Nasmyth, O'Brien, Onn, Ptacin, Reyes-Lamothe, Ringgaard, Salje, Sambrook, Schofield, Scholefield, Sebert, Soppa, Sullivan, Terzaghi, Thanbichler, Toro, van der Poll, Weiser, Yu, Zakrzewska-Czerwinska, Zhao   +61 more
core   +5 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source