Results 211 to 220 of about 776,748 (351)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein-DNA complexes. [PDF]

RSC Chem Biol
Šoltysová M, Güixens-Gallardo P, Sieglová I, Soldánová A, Krejčiříková V, Fábry M, Brynda J, Khoroshyy P, Hocek M, Řezáčová P.   +9 more
europepmc   +1 more source

Effect of co-axially hybridized gene targets on hybridization efficiency of microarrayed DNA probes

, 2010
Kai Jiang, Jie-Len Huang, Chia‐Chun Chen, Hung-Ju Su, Jui‐Chuang Wu   +4 more
openalex   +2 more sources

On-Bead DNA Synthesis Triggered by Allosteric Probe for Sensitive Detection of Protein Biomarker

, 2022
Shengbin He, Min Ling, Na Luo, Lanyu Cui, Yongqiang Cao, Xueping Ning, Jian Sun, Yutong Li, Mei R. Fu   +8 more
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Quantitative and spatially resolved detection of multiplexed microRNA from plant tissue via hybridization to hydrogel-bound DNA probes in nanoliter well arrays. [PDF]

Microsyst Nanoeng
Fang J, Doyle PS.
europepmc   +1 more source

Design and PCR Synthesis of Infrared Fluorophore-Labeled Modular DNA Probes v1 [PDF]

, 2018
Michael W. Van Dyke
openalex   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Nanostructure and Corresponding Quenching Efficiency of Fluorescent DNA Probes. [PDF]

Materials (Basel), 2018
Guo W, Wei Y, Dai Z, Chen G, Chu Y, Zhao Y.   +5 more
europepmc   +1 more source