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JAMA, 1987
The emergence of recombinant DNA technology in the 1970s has given rise to new diagnostic techniques based on DNA probes. The Food and Drug Administration's interest in these probes stems from its regulatory responsibilities regarding DNA probes as medical devices. The agency also sees DNA probes as valuable tools in meeting its mission of identifying,
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The emergence of recombinant DNA technology in the 1970s has given rise to new diagnostic techniques based on DNA probes. The Food and Drug Administration's interest in these probes stems from its regulatory responsibilities regarding DNA probes as medical devices. The agency also sees DNA probes as valuable tools in meeting its mission of identifying,
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Probing Mouse Origins with Random DNA Probes
1988Until not so long ago, many villages and towns used to have their own chroniclers who took it upon themselves to record for posterity those events which they believed to be the most important in the life of the community. They were, of course, no professionals; they were farmers, bakers, shoemakers, or pursued whatever occupation happened to be in ...
J, Klein +3 more
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2003
Many research workers and clinicians working in routine laboratories are now using the "tools" developed by molecular biologists over the past 10 years to produce DNA sequences that can be used as probes to detect specific genes. Thus it is possible to screen food for salmonella (1) or other organisms in a test much more quickly than conventional ...
J L, Woodhead +3 more
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Many research workers and clinicians working in routine laboratories are now using the "tools" developed by molecular biologists over the past 10 years to produce DNA sequences that can be used as probes to detect specific genes. Thus it is possible to screen food for salmonella (1) or other organisms in a test much more quickly than conventional ...
J L, Woodhead +3 more
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Probing DNA Structure With Nanoparticles
2005Semiconductor nanoparticles, also known as quantum dots, are receiving increasing attention for their biological applications. These nanomaterials are photoluminescent and are being developed both as dyes and as sensors. Here we describe our "sensor" use of quantum dots to detect different intrinsic DNA structures.
Rahina, Mahtab, Catherine J, Murphy
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Probing the Security of DNA Origami
2018 IEEE International Symposium on Software Reliability Engineering Workshops (ISSREW), 2018DNA origami is a method used to program the self-assembly of nanoscale computational systems. The contribution of this paper is to probe the security of a canonical DNA origami that is often reused. The paper describes the techniques we used to design probes whose input targets the origami systems' integrity.
Chase Koehler +3 more
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Small DNA circles as probes of DNA topology
Biochemical Society Transactions, 2013Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA.
Andrew D, Bates +4 more
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Probing RNA Translocases with DNA
2014For some helicases, it is possible to investigate RNA translocase activity on DNA substrates because the enzyme acts on both substrates. Potassium permanganate (KMnO4) footprinting is a method used to chemically probe the conformation of DNA as well as the binding of proteins.
Kimberly A, Reynolds +2 more
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Diagnostic Applications of DNA Probes
Infection Control & Hospital Epidemiology, 1991The use of recombinant DNA technology to develop specific molecular (usually DNA) probes has provided medical and veterinary diagnostic laboratories with powerful new tools to enhance the diagnosis of infectious diseases, genetic disorders, and malignancies, as well as more sensitive and specific means to accomplish such tasks as tissue typing and ...
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DNA Probes in Diagnostic Pathology
American Journal of Clinical Pathology, 1988Molecular pathology has become firmly established as a distinctive discipline in medicine. It has introduced radical changes in concepts of disease causation and in classification of disease states affecting humans and other organisms. In addition, molecular pathology represents a "new" diagnostic technology with many potentials that have been ...
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Nanoparticles and DNA Probes Based on DNA‐Fluorophore Conjugates
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Abdalla, M. +3 more
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