Results 371 to 380 of about 3,927,360 (403)

Binding-induced fluorescence turn-on assay using aptamer-functionalized silver nanocluster DNA probes.

Analytical Chemistry, 2012
We present here a binding-induced fluorescence turn-on assay for protein detection. Key features of this assay include affinity binding-induced DNA hybridization and fluorescence enhancement of silver nanoclusters (Ag NCs) using guanine-rich DNA ...
Jingjing Li, Xiaoqin Zhong, Hongquan Zhang, X. Le, Jun‐Jie Zhu   +4 more
semanticscholar   +1 more source

Enzyme-Labeled DNA Probes

2003
Many research workers and clinicians working in routine laboratories are now using the "tools" developed by molecular biologists over the past 10 years to produce DNA sequences that can be used as probes to detect specific genes. Thus it is possible to screen food for salmonella (1) or other organisms in a test much more quickly than conventional ...
J. Lesley Woodhead, Rachel A. Fallon, Hermia Figueiredo, Alan D. B. Malcolm   +3 more
openaire   +3 more sources

Small DNA circles as probes of DNA topology

Biochemical Society Transactions, 2013
Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA.
Anthony Maxwell, Agnes Noy, Andrew D. Bates, Michael M. Piperakis, Sarah A. Harris   +4 more
openaire   +3 more sources

Probing DNA Structure With Nanoparticles

2005
Semiconductor nanoparticles, also known as quantum dots, are receiving increasing attention for their biological applications. These nanomaterials are photoluminescent and are being developed both as dyes and as sensors. Here we describe our "sensor" use of quantum dots to detect different intrinsic DNA structures.
Catherine J. Murphy, Rahina Mahtab
openaire   +3 more sources

Supersandwich cytosensor for selective and ultrasensitive detection of cancer cells using aptamer-DNA concatamer-quantum dots probes.

Analytical Chemistry, 2013
In this work, a signal amplification supersandwich strategy was developed for highly selective and sensitive detection of cancer cells using aptamer-DNA concatamer-quantum dots (QDs) probes.
Hongying Liu, Shouming Xu, Zhimei He, Anping Deng, Jun‐Jie Zhu   +4 more
semanticscholar   +1 more source

DNA Probes in Diagnostic Pathology

American Journal of Clinical Pathology, 1988
Molecular pathology has become firmly established as a distinctive discipline in medicine. It has introduced radical changes in concepts of disease causation and in classification of disease states affecting humans and other organisms. In addition, molecular pathology represents a "new" diagnostic technology with many potentials that have been ...
openaire   +3 more sources

Probing Amyloid-DNA Interaction with Nanofluidics

2022
Nanofluidics is an emerging methodology to investigate single biomacromolecules without functionalization and/or attachment of the molecules to a substrate. In conjunction with fluorescence microscopy, it can be used to investigate structural and dynamical aspects of amyloid-DNA interaction.
Basak, Rajib, Yadav, Indresh, Arluison, Véronique, van Kan, Jeroen, van der Maarel, Johan   +4 more
openaire   +3 more sources

DNA probes in microbiology

1985
The successful diagnosis of a microbial infection is dependent on the ability to confirm the presence of material from pathogenic microorganisms in clinical samples. The diagnostic approaches will vary according to the clinical situation but any test must be able to identify a potential pathogen, or material from that pathogen, amongst complex ...
openaire   +2 more sources

Controlled and efficient hybridization achieved with DNA probes immobilized solely through preferential DNA-substrate interactions.

Analytical Chemistry, 2010
Quantitative and reproducible data can be obtained from surface-based DNA sensors if variations in the conformation and surface density of immobilized single-stranded DNA capture probes are minimized.
S. M. Schreiner, David F Shudy, Anna L. Hatch, A. Opdahl, L. Whitman, D. Petrovykh   +5 more
semanticscholar   +1 more source

Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection.

Science, 2002
Multiplexed detection of oligonucleotide targets has been performed with gold nanoparticle probes labeled with oligonucleotides and Raman-active dyes.
Y. Cao, Rongchao Jin, C. Mirkin
semanticscholar   +1 more source