Results 41 to 50 of about 750,684 (287)

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Sequence Heterogeneity Accelerates Protein Search for Targets on DNA [PDF]

, 2015
The process of protein search for specific binding sites on DNA is fundamentally important since it marks the beginning of all major biological processes. We present a theoretical investigation that probes the role of DNA sequence symmetry, heterogeneity
Alberts B., Alexey A. Shvets, Anatoly B. Kolomeisky, Dill K. A., Lodish H., Phillips R.   +5 more
core   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Hibridación in situ fluorescente (FISH) [PDF]

, 2016
Background: At the end of 80s, cloning technologies with the increase of the antibodies’ sensibility made easier the development of technologies based on Fluorescence in situ Hibridation (FISH).
Aguilar, Ruben, Montoro, Carolina
core  

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]

, 2015
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C, Ashworth, A, Baglietto, L, Chadeau, M, Curry, E, Flanagan, JM, Flower, K, Frasca, G, Garcia-Closas, M, Jones, M, Krogh, V, Lund, E, Masala, G, Mattiello, A, Orr, N, Palli, D, Panico, S, Polidoro, S, Sacerdote, C, Sandanger, T, Severi, G, Swerdlow, A, Tomczyk, K, Tumino, R, van veldhoven, K, vineis, P   +25 more
core   +5 more sources

DNA probe for identification of Streptococcus pneumoniae [PDF]

Journal of Clinical Microbiology, 1989
A total of 287 clinical isolates of Streptococcus pneumoniae (pneumococcus) were tested for their ability to undergo autolysis when treated with sodium deoxycholate. The test was positive for all but one isolate, strain DOC-1. This autolysis required the activity of an enzyme which is unique and characteristic of S.
Pozzi G, Oggioni MR, Tomasz A.
openaire   +4 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Long-Range Chromosomal Mapping of the Carcinoembryonic Antigen (CEA) Gene Family Cluster [PDF]

, 1992
A long-range physical map of the carcinoembryonic antigen (CEA) gene family cluster, which is located on the long arm of chromosome 19, has been constructed.
Arakawa, Barnett, Barnett, Barnett, Benchimol, Berling, Bird, Bischoff-Delaloye, Bohn, Bordes, Brandriff, Branscomb, Brook, Brook, Brook, Carrano, Carrano, Chomczynski, Church, de Jong, Efstratiadis, Feinberg, Fritsch, Gold, Gold, Hinoda, Hinoda, Holland, Huang, Kamarck, Kodelja, Kuroki, Leusch, Lin, Mach, Maniatis, Nap, Niemann, Oikawa, Paxton, Pignatelli, Ropers, Sambrook, Sanger, Schonk, Schrewe, Schwartz, Sharkey, Shively, Slightom, Stallings, Steinmetz, Streydio, Svenberg, Tatarinov, Tatarinov, Thompson, Thompson, Thompson, Thompson, Thompson, Tonegawa, von Kleist, von Kleist, Willcocks, Willcocks, Willcocks, Zimmermann, Zimmermann, Zimmermann   +69 more
core   +1 more source