Results 101 to 110 of about 674,033 (286)

Genome-wide profiling of unmodified DNA using methyltransferase-directed tagging and enrichment

Cell Reports: Methods
Summary: We present “Active-Seq” (azide click tagging for in vitro epigenomic sequencing), a base-conversion-free technology that enables the isolation of DNA containing unmodified CpG sites using a mutated bacterial methyltransferase enzyme and a ...
Luca Tosti, Calum Mould, Imogen Gatehouse, Anthony C. Smith, Krystian Ubych, Valentina Miano, Peter W. Laird, Jack Kennefick, Robert K. Neely   +8 more
doaj   +1 more source

Recent advances in the application of stable isotope ratio analysis in forensic chemistry [PDF]

, 2010
This review paper updates the previous literature in relation to the continued and developing use of stable isotope ratio analysis in samples which are relevant to forensic science.
Benson, Benson, Benson, Bernstein, Besacier, Billault, Bowen, Brenna, Buchanan, Carter, Carter, Casale, de Korompay, Desage, Ehleringer, Ehleringer, Farmer, Farmer, Fraser, Fraser, Hilary A. S. Buchanan, James G. Fraser, Kathleen A. Savage, Kelly, Kurashima, Lock, Mas, Meier-Augenstein, Meier-Augenstein, Meier-Augenstein, Niamh Nic Daeid, Nissenbaum, Palhol, Pierrini, Podlesak, Quirk, Sarah L. Cresswell, Shibuya, Taylor, van Es, Widory   +40 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

DNA PROFILING

Open Schools Journal for Open Science
DNA, a complex molecule found in all living organisms, carries vital information for their construction. Inherited from one generation to the next, DNA is present in nearly every cell of multicellular organisms, resembling a double helix structure. DNA profiling, pioneered in 1984 by Dr.
openaire   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

DNA methylation-based classification of central nervous system tumours. [PDF]

, 2018
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-
Aronica, Eleonora, Becker, Albert, Benner, Axel, Beschorner, Rudi, Bewerunge-Hudler, Melanie, Bjerkvig, Rolf, Braczynski, Anne K, Brehmer, Stefanie, Brück, Wolfgang, Calaminus, Gabriele, Capper, David, Chavez, Lukas, Coras, Roland, Cryan, Jane, Deckert, Martina, Dohmen, Hildegard, Driever, Pablo Hernáiz, Engel, Nils W, Farrell, Michael, Fischer, Roger, Fleischhack, Gudrun, Frank, Stephan, Frühwald, Michael C, Garvalov, Boyan K, Geisenberger, Christoph, Giangaspero, Felice, Gnekow, Astrid, Gottardo, Nicholas G, Haberler, Christine, Hans, Volkmar, Hansford, Jordan R, Harter, Patrick N, Hench, Jürgen, Heppner, Frank, Hewer, Ekkehard, Hofer, Silvia, Hovestadt, Volker, Huang, Kristin, Hänggi, Daniel, Hölsken, Annett, Jones, Chris, Jones, David TW, Jouvet, Anne, Kannan, Kasthuri, Keohane, Catherine, Ketter, Ralf, Khatib, Ziad, Koch, Arend, Koelsche, Christian, Kohlhof, Patricia, Kramm, Christof M, Kratz, Annekathrin, Kristensen, Bjarne W, Kulozik, Andreas, Lechner, Matt, Lindenberg, Kerstin, Lohmann, Dietmar, Lopes, Beatriz, Mawrin, Christian, Milde, Till, Monoranu, Camelia-Maria, Mueller, Wolf, Mühleisen, Helmut, Müller, Hermann L, Olar, Adriana, Pages, Melanie, Pajtler, Kristian W, Perry, Arie, Plate, Karl H, Pohl, Ute, Preusser, Matthias, Prinz, Marco, Reuss, David E, Rodriguez, Fausto J, Rozsnoki, Stephanie, Rushing, Elisabeth, Rutkowski, Stefan, Sahm, Felix, Scheurlen, Wolfram, Schick, Matthias, Schittenhelm, Jens, Schrimpf, Daniel, Schweizer, Leonille, Seiz-Rosenhagen, Marcel, Selt, Florian, Serrano, Jonathan, Sill, Martin, Staszewski, Ori, Stichel, Damian, Sturm, Dominik, Temming, Petra, Tippelt, Stephan, Tsirigos, Aristotelis, Varlet, Pascale, von Hoff, Katja, Wani, Khalida, Wefers, Annika K, Witt, Hendrik, Witt, Olaf, Zapatka, Marc   +99 more
core   +1 more source

Systematic alteration of ATAC-seq for profiling open chromatin in cryopreserved nuclei preparations from livestock tissues. [PDF]

, 2020
The use of Assay for Transposase-Accessible Chromatin (ATAC-seq) to profile chromatin accessibility has surged over the past years, but its applicability to tissues has been very limited.
Chanthavixay, G, Delany, ME, Halstead, MM, Kern, C, Ross, PJ, Saelao, P, Wang, Y, Zhou, H   +7 more
core   +1 more source

Analysis of DNA profiles of ash (Fraxinus excelsior L.) to provide evidence of illegal logging [PDF]

, 2017
The present work formed part of a research project supported by the General Directorate of State Forests (Grants BLP-333 and BLP-384). We gratefully acknowledge the Forest Guard staff from Śnieżka Forest District for their efficient cooperation.
Borys, Malgorzata, Konecka, Agata, Nowakowska, Justyna Anna, Tereba, Anna, Woodward, Stephen   +4 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Extraction Strategy for DNA Recovery from Putrefied Teeth and Skull Bone

Arab Journal of Forensic Sciences & Forensic Medicine, 2016
Forensic samples are commonly exposed to harsh environmental conditions which affect the degree of sample (DNA) preservation and subsequent genetic profiling.
Arwa Kamoun, Wiem Ben Amar, Nadia Mahfoudh, Leila Maalej, Bakhta Mallek, Youssef Nouma, Sami Bardaa, Hafedh Makni, Samir Maatoug   +8 more
doaj   +1 more source