Results 131 to 140 of about 674,033 (286)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma

Acta Neuropathologica Communications
Pineoblastoma is a rare and aggressive malignancy that often affects pediatric populations. Accurate diagnosis is challenging due to histological overlap with other central nervous system tumors and limited molecular data.
Celeste Antonacci, Luana Abballe, Sara Patrizi, Lucia Pedace, Sabina Barresi, Isabella Giovannoni, Chantal Tancredi, Flavia Vinciarelli, Giacomina Megaro, Andrea Carai, Sabrina Rossi, Franco Locatelli, Angela Mastronuzzi, Evelina Miele   +13 more
doaj   +1 more source

Genome-Wide Extrachromosomal Circular DNA Profiling of Paired Hepatocellular Carcinoma and Adjacent Liver Tissues. [PDF]

Cancers (Basel), 2023
Ye J, Huang P, Ma K, Zhao Z, Hua T, Zai W, Chen J, Fu X.   +7 more
europepmc   +1 more source

The rarity of DNA profiles

The Annals of Applied Statistics, 2007
Published in at http://dx.doi.org/10.1214/07-AOAS128 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
openaire   +4 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

DNA methylation profiling in archived FFPE renal biopsies: a pilot study of epigenetic markers of albuminuria in diabetic kidney disease

Epigenetics Reports
Diabetes Mellitus is the leading risk factor for kidney failure, yet current biomarkers such as urinary albumin-to-creatinine ratio (UACR) lack tissue specificity and sensitivity for early detection of Diabetic Kidney Disease (DKD).
Ishant Khurana, Ram Abou Zaki, Harikrishnan Kaipananickal, Rachel Njeim, Batoul Dia, Hala Kfoury Kassouf, Assaad A. Eid, Assam El-Osta   +7 more
doaj   +1 more source

Evaluating the Usefulness of Human DNA Quantification to Predict DNA Profiling Success of Historical Bone Samples. [PDF]

Genes (Basel), 2023
Thomas JT, Cavagnino C, Kjelland K, Anderson E, Sturk-Andreaggi K, Daniels-Higginbotham J, Amory C, Spatola B, Moran K, Parson W, Marshall C.   +10 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas. [PDF]

J Clin Oncol, 2023
Mutter JA, Alig SK, Esfahani MS, Lauer EM, Mitschke J, Kurtz DM, Kühn J, Bleul S, Olsen M, Liu CL, Jin MC, Macaulay CW, Neidert N, Volk T, Eisenblaetter M, Rauer S, Heiland DH, Finke J, Duyster J, Wehrle J, Prinz M, Illerhaus G, Reinacher PC, Schorb E, Diehn M, Alizadeh AA, Scherer F.   +26 more
europepmc   +1 more source