Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices.
PLoS ONE, 2010 BackgroundEmerging evidence suggests that DNA methylation plays an expansive role in the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of ...
Yurong Xin +11 more
doaj +1 more source
Interspecific differences between the DNA restriction profiles of canine adenoviruses [PDF]
, 1984 Claude Hamelin +2 more
openalex +1 more source
Simultaneous profiling of 3D genome structure and DNA methylation in single human cells
Nature Methods, 2019 Dynamic three-dimensional chromatin conformation is a critical mechanism for gene regulation during development and disease. Despite this, profiling of three-dimensional genome structure from complex tissues with cell-type specific resolution remains ...
Dong-Sung Lee +10 more
semanticscholar +1 more source
Twist-stretch profiles of DNA chains [PDF]
Journal of Physics: Condensed Matter, 2017 Helical molecules change their twist number under the effect of a mechanical load. We study the twist-stretch relation for a set of short DNA molecules modeled by a mesoscopic Hamiltonian. Finite temperature path integral techniques are applied to generate a large ensemble of possible configurations for the base pairs of the sequence.
openaire +4 more sources
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Taxonomic Differentiation of Bacteriophages of Lactococcus lactis by Electron Microscopy, DNA-DNA Hybridization, and Protein Profiles [PDF]
, 1989 V. Braun +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
[Inferences Using DNA Profiling in Forensic Identification and Paternity Cases]: Comment: Uncertainty in DNA Profile Evidence [PDF]
, 1991 David H. Kaye
openalex +1 more source
Fructan biosynthesis in Lolium perenne : tissue, cultivar and temperature effects on gene expression and protein accumulation profiles : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University, Palmerston North, New Zealand [PDF]
, 2008 Cultivars of Lolium perenne with high concentrations of water soluble carbohydrates (WSCs) offer opportunities to mitigate greenhouse gas emissions (nitrous oxides) from grazed pastures and improve meat and milk production in livestock.
Xue, Hong
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