Results 171 to 180 of about 5,488,409 (376)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas. [PDF]

J Clin Oncol, 2023
Mutter JA, Alig SK, Esfahani MS, Lauer EM, Mitschke J, Kurtz DM, Kühn J, Bleul S, Olsen M, Liu CL, Jin MC, Macaulay CW, Neidert N, Volk T, Eisenblaetter M, Rauer S, Heiland DH, Finke J, Duyster J, Wehrle J, Prinz M, Illerhaus G, Reinacher PC, Schorb E, Diehn M, Alizadeh AA, Scherer F.   +26 more
europepmc   +1 more source

Gene Expression Profiling by DNA Microarrays and Metabolic Fluxes in Escherichia coli [PDF]

, 2000
Min‐Kyu Oh, James C. Liao
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma

Acta Neuropathologica Communications
Pineoblastoma is a rare and aggressive malignancy that often affects pediatric populations. Accurate diagnosis is challenging due to histological overlap with other central nervous system tumors and limited molecular data.
Celeste Antonacci, Luana Abballe, Sara Patrizi, Lucia Pedace, Sabina Barresi, Isabella Giovannoni, Chantal Tancredi, Flavia Vinciarelli, Giacomina Megaro, Andrea Carai, Sabrina Rossi, Franco Locatelli, Angela Mastronuzzi, Evelina Miele   +13 more
doaj   +1 more source

A High-Grade Glioma, Not Elsewhere Classified in an Older Adult with Discordant Genetic and Epigenetic Analyses

Biomedicines
The World Health Organization’s (WHO) classification of central nervous system (CNS) tumors is continually being refined to improve the existing diagnostic criteria for high-grade gliomas (HGGs), including glioblastoma.
Carlen A. Yuen, Silin Bao, Xiao-Tang Kong, Merryl Terry, Alexander Himstead, Michelle Zheng, Melike Pekmezci   +6 more
doaj   +1 more source

Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis. [PDF]

BMC Med, 2023
Zhong R, Gao R, Fu W, Li C, Huo Z, Gao Y, Lu Y, Li F, Ge F, Tu H, You Z, He J, Liang W.   +12 more
europepmc   +1 more source

Optimized RAPD Analysis Generates High-Quality Genomic DNA Profiles at High Annealing Temperature [PDF]

, 2000
Franck Atienzar, Andrew J. Evenden, Awadhesh N. Jha, D. Savva, Michael H. Depledge   +4 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

The Influence of Formamide on Thermal Denaturation Profiles of DNA and Metaphase Chromosomes in Suspension [PDF]

, 2000
Joachim Rauch, Dietmar Wolf, Michael Hausmann, Christoph Cremer   +3 more
openalex   +1 more source