Results 1 to 10 of about 874,932 (242)

Optimality in DNA repair [PDF]

Journal of Theoretical Biology, 2012
Peer reviewedPublisher ...
Aksenov, Alessandro Moura, Bronk, Celso Grebogi, Doudney, Gillespie, Harm, Husain, Ian Booth, Karschau, Kesseler, Krasin, Matthew Fryett, Morgiane Richard, Moss, Mouri, Myles, Ni, Pennington, Politi, Rupp, Samantha Miller, Sancar, Sancar, Sancar, Shimoni, Wyman   +26 more
core   +5 more sources

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

Cells, 2023
APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that maintains genome stability. It was identified as a pivotal factor favoring tumor progression and chemoresistance through the control of gene expression by a redox-based ...
Matilde Clarissa Malfatti, Alessia Bellina, Giulia Antoniali, Gianluca Tell   +3 more
doaj   +1 more source

NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells

Scientific Reports, 2023
Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways by preventing ...
Umit Aliyaskarova, Yeldar Baiken, Flore Renaud, Sophie Couve, Alexei F. Kisselev, Murat Saparbaev, Regina Groisman   +6 more
doaj   +1 more source

DNA Repair [PDF]

WormBook, 2006
The integrity of the genome is essential to the health of the individual and to the reproductive success of a species. Transmission of genetic information is in a selective balance between two opposing forces, the maintenance of genetic stability versus elimination of mutational change and loss of evolutionary potential. Caenorhabditis elegans provides
Nigel, O'Neil, Ann, Rose
openaire   +2 more sources

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function

Communications Biology, 2020
Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype.
Gloria X. Reyes, Boyu Zhao, Tobias T. Schmidt, Kerstin Gries, Matthias Kloor, Hans Hombauer   +5 more
doaj   +1 more source

DNA repair nucleases [PDF]

Cellular and Molecular Life Sciences (CMLS), 2004
Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and endogenous agents or introduced by DNA metabolism, such as replication. Most repair mechanisms include nucleolytic processing of DNA, where nucleases cleave a phosphodiester bond between a deoxyribose and a phosphate residue ...
Oliver Fleck, Oliver Fleck, Thomas M. Marti   +2 more
openaire   +5 more sources

Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration.
Xixia Chu, Yujun Hou, Yujun Hou, Qiong Meng, Deborah L. Croteau, Deborah L. Croteau, Yong Wei, Supriyo De, Kevin G. Becker, Vilhelm A. Bohr   +9 more
doaj   +1 more source

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Nature Communications, 2023
Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek, Simone Kunzelmann, Andrew G. Purkiss, Mariana Silva Dos Santos, James I. MacRae, Ian A. Taylor, Kasper Fugger, Stephen C. West   +7 more
doaj   +1 more source

DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae [PDF]

, 1995
The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiation was studied by analysis of postirradiation molecular weight changes in cellular DNA.
Budd, Martin E., Campbell, Judith L.
core   +2 more sources