Results 1 to 10 of about 3,275,727 (250)
DNA Repair Pathways in Cancer Therapy and Resistance
Frontiers in Pharmacology, 2021 DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li +4 more
semanticscholar +1 more source
DNA repair defects in cancer and therapeutic opportunities
Genes & Development, 2022 In this review, Hopkins et al. review the major classes of DNA repair and damage signaling defects in cancer, the genomic instability that they give rise to, and therapeutic strategies to exploit the resulting vulnerabilities.
Jessica Hopkins, Li Lan, L. Zou
semanticscholar +1 more source
Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons
Cells, 2023 APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that maintains genome stability. It was identified as a pivotal factor favoring tumor progression and chemoresistance through the control of gene expression by a redox-based ...
Matilde Clarissa Malfatti +3 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar +1 more source
Scientific Reports, 2023 Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways by preventing ...
Umit Aliyaskarova +6 more
doaj +1 more source
Experientia, 2020 DNA fi ber fl uorography is widely employed to study the kinetics of DNA replication, but the usefulness of this approach has been limited by the lack of freely-available automated analysis tools.
Marta Codrich +9 more
semanticscholar +1 more source
Loop extrusion as a mechanism for DNA damage repair foci formation
Nature, 2021 The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX
C. Arnould +12 more
semanticscholar +1 more source
WormBook, 2006 The integrity of the genome is essential to the health of the individual and to the reproductive success of a species. Transmission of genetic information is in a selective balance between two opposing forces, the maintenance of genetic stability versus elimination of mutational change and loss of evolutionary potential. Caenorhabditis elegans provides
Nigel, O'Neil, Ann, Rose
openaire +2 more sources
Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
Communications Biology, 2020 Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype.
Gloria X. Reyes +5 more
doaj +1 more source
Optimality in DNA repair [PDF]
Journal of Theoretical Biology, 2012 DNA within cells is subject to damage from various sources. Organisms have evolved a number of mechanisms to repair DNA damage. The activity of repair enzymes carries its own risk, however, because the repair of two nearby lesions may lead to the breakup of DNA and result in cell death.
Richard, Morgiane Carole +5 more
openaire +3 more sources