Results 1 to 10 of about 592,198 (269)

Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets

Frontiers in Bioinformatics
Functional enrichment analysis (FEA) provides biological meaning from lists of differentially expressed genes and proteins obtained through omics experiments. FEA tools can employ numerous statistical methods and rely on different pathway databases.
Fábio Henrique Schuster de Oliveira, Felipe Acker Gomes, Bruno César Feltes   +2 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology
Targeted and immune therapies have improved patient outcomes in selected diseases. Still, resistance inevitably occurs, and a significant portion of the proteome remains undruggable due to target localisation, structural or functional constraints ...
Noé Herbel, Sophie Postel‐Vinay
doaj   +1 more source

A practical guide to functional enrichment analysis

Frontiers in Bioinformatics
Functional Enrichment Analysis (FEA) has become a critical step in the analysis of omics data in recent years. As a result, numerous approaches have been rapidly developed, leading to an overflow of information that can be difficult for beginners to ...
Fábio Henrique Schuster de Oliveira, Lucas Giron dos Santos, Bruno César Feltes   +2 more
doaj   +1 more source

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam

Cell Death and Disease
Mitochondrial dysfunction is a central aspect of Parkinson’s disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer ...
Velmarini Vasquez, Manohar Kodavati, Joy Mitra, Indira Vedula, Dale J. Hamilton, Ralph M. Garruto, K. S. Rao, Muralidhar L. Hegde   +7 more
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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease

Nature Communications
This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS ...
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Vincent Provasek, Vikas H. Maloji Rao, Indira Vedula, Aijun Zhang, Sankar Mitra, Alan E. Tomkinson, Dale J. Hamilton, Ludo Van Den Bosch, Muralidhar L. Hegde   +13 more
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Red propolis: Chemical composition and pharmacological activity

Asian Pacific Journal of Tropical Biomedicine, 2017
Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13 groups based on their organoleptics and physicochemical characteristics. The 13th type named red
Luciane Corbellini Rufatto, Denis Amilton dos Santos, Flávio Marinho, João Antonio Pêgas Henriques, Mariana Roesch Ely, Sidnei Moura   +5 more
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Differences in the Response to DNA Double-Strand Breaks between Rod Photoreceptors of Rodents, Pigs, and Humans

Cells, 2020
Genome editing (GE) represents a powerful approach to fight inherited blinding diseases in which the underlying mutations cause the degeneration of the light sensing photoreceptor cells of the retina.
Florian Frohns, Antonia Frohns, Johanna Kramer, Katharina Meurer, Carla Rohrer-Bley, Irina Solovei, David Hicks, Paul G. Layer, Markus Löbrich   +8 more
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Histological and Immunohistochemical Protocol to Study Different Degrees of Severity of Lumbar Degenerative Discopathy

Global Spine Journal, 2014
Introduction Literature on histological and immunohistochemical protocols that relate degenerative discopathy and its degree of wear is scarce. The purpose of this study was to analyze the structural degeneration of the intervertebral disc of patients ...
A. Falavigna, M. Peletti-Figueiró, I. Silvera Aguiar, M. Roesch-Ely, D. Cantarelli Machado, J. A. Pêgas Henriques, O. Righesso   +6 more
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The Role of NCOA4-Mediated Ferritinophagy in Health and Disease

Pharmaceuticals, 2018
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy„), the cytosolic iron storage complex.
Naiara Santana-Codina, Joseph D. Mancias
doaj   +1 more source

Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes

Nature Communications
Transition of cytosine to thymine in CpG dinucleotides is the most frequent type of mutation in cancer. This increased mutability is commonly attributed to the spontaneous deamination of 5-methylcytosine (5mC), which is normally repaired by the base ...
André Bortolini Silveira, Alexandre Houy, Olivier Ganier, Begüm Özemek, Sandra Vanhuele, Anne Vincent-Salomon, Nathalie Cassoux, Pascale Mariani, Gaelle Pierron, Serge Leyvraz, Damian Rieke, Alberto Picca, Franck Bielle, Marie-Laure Yaspo, Manuel Rodrigues, Marc-Henri Stern   +15 more
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