Results 1 to 10 of about 3,775,125 (290)

DNA Repair Pathways in Cancer Therapy and Resistance

Frontiers in Pharmacology, 2021
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li, Yi-di Guan, Xi-sha Chen, Jin-Ming Yang, Yan Cheng   +4 more
semanticscholar   +1 more source

DNA repair defects in cancer and therapeutic opportunities

Genes & Development, 2022
In this review, Hopkins et al. review the major classes of DNA repair and damage signaling defects in cancer, the genomic instability that they give rise to, and therapeutic strategies to exploit the resulting vulnerabilities.
Jessica Hopkins, Li Lan, L. Zou
semanticscholar   +1 more source

Structural basis of human transcription–DNA repair coupling

Nature, 2021
Transcription-coupled DNA repair removes bulky DNA lesions from the genome1,2 and protects cells against ultraviolet (UV) irradiation3. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the ...
G. Kokic, F. R. Wagner, A. Chernev, H. Urlaub, P. Cramer   +4 more
semanticscholar   +1 more source

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2021
Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar   +1 more source

DNA repair

Experientia, 2020
is becoming a promising target in cancer therapy and a powerful prognostic and predictive factor in several cancer types. Thus, speci fi c APE1 inhibitors have been developed targeting: i) the endonuclease activity; ii) the redox function and iii) the ...
Marta Codrich, Marina Comelli, M. Malfatti, Catia Mio, D. Ayyildiz, Chi Zhang, Mark R. Kelley, Giovanni Terrosu, Carlo E M Pucillo, Gianluca Tell   +9 more
semanticscholar   +1 more source

Loop extrusion as a mechanism for DNA damage repair foci formation

Nature, 2021
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX
C. Arnould, V. Rocher, Anne-Laure Finoux, T. Clouaire, Kevin Li, Felix Zhou, P. Caron, P. Mangeot, Emiliano P. Ricci, R. Mourad, J. Haber, D. Noordermeer, G. Legube   +12 more
semanticscholar   +1 more source

DNA Damage/Repair Management in Cancers

Cancers, 2020
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
Jehad F Alhmoud, J. Woolley, A. Al Moustafa, M. I. Malki   +3 more
semanticscholar   +1 more source

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Genome Biology, 2016
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts.
R. Rosenthal, N. Mcgranahan, Javier Herrero, B. Taylor, C. Swanton   +4 more
semanticscholar   +1 more source

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

Nature
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2.
Hengxing Chen, Yun Li, Hua-fu Li, Xiancong Chen, Hua-Feng Fu, Deli Mao, Wei Chen, Linxiang Lan, Chun-ming Wang, K. Hu, Jia Li, Chengming Zhu, I. Evans, Eddie Cheung, Daning Lu, Yulong He, Axel Behrens, Dong Yin, Changhua Zhang   +18 more
semanticscholar   +1 more source

The Shieldin complex mediates 53BP1-dependent DNA repair

Nature, 2018
53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini1,2. This function of 53BP1 requires interactions with PTIP3 and RIF14–9, the latter of which recruits REV7 (
S. M. Noordermeer, Salomé Adam, Dheva Setiaputra, M. Barazas, S. Pettitt, Alexanda K. Ling, Michele Olivieri, Alejandro Álvarez-Quilón, N. Moatti, Michal Zimmermann, S. Annunziato, Dragomir B. Krastev, F. Song, I. Brandsma, J. Frankum, R. Brough, Alana Sherker, S. Landry, R. Szilard, Meagan M. Munro, Andrea McEwan, T. Goullet de Rugy, Zhen-Yuan Lin, Traver Hart, J. Moffat, A. Gingras, Alberto Martin, Haico van Attikum, J. Jonkers, C. Lord, S. Rottenberg, D. Durocher   +31 more
semanticscholar   +1 more source