Results 1 to 10 of about 3,810,652 (392)
Neurobiology of Disease, 2023 RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA replication, recombination, and DNA repair. In human cells, there are five RecQ helicases: RECQL1, Bloom syndrome (BLM), Werner syndrome (WRN), RECQL4, and ...
Yujun Hou +7 more
doaj +1 more source
GEN1 promotes common fragile site expression
Cell Reports, 2023 Summary: Our genomes harbor conserved DNA sequences, known as common fragile sites (CFSs), that are difficult to replicate and correspond to regions of genome instability.
Anaid Benitez +6 more
doaj +1 more source
DNA Repair Pathways in Cancer Therapy and Resistance
Frontiers in Pharmacology, 2021 DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li +4 more
semanticscholar +1 more source
Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons
Cells, 2023 APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that maintains genome stability. It was identified as a pivotal factor favoring tumor progression and chemoresistance through the control of gene expression by a redox-based ...
Matilde Clarissa Malfatti +3 more
doaj +1 more source
DNA repair defects in cancer and therapeutic opportunities
Genes & Development, 2022 In this review, Hopkins et al. review the major classes of DNA repair and damage signaling defects in cancer, the genomic instability that they give rise to, and therapeutic strategies to exploit the resulting vulnerabilities.
Jessica Hopkins, Li Lan, L. Zou
semanticscholar +1 more source
Scientific Reports, 2023 Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways by preventing ...
Umit Aliyaskarova +6 more
doaj +1 more source
Structural basis of human transcription–DNA repair coupling
Nature, 2021 Transcription-coupled DNA repair removes bulky DNA lesions from the genome1,2 and protects cells against ultraviolet (UV) irradiation3. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the ...
G. Kokic +4 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar +1 more source
DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
core +1 more source
Experientia, 2020 is becoming a promising target in cancer therapy and a powerful prognostic and predictive factor in several cancer types. Thus, speci fi c APE1 inhibitors have been developed targeting: i) the endonuclease activity; ii) the redox function and iii) the ...
Marta Codrich +9 more
semanticscholar +1 more source