Results 231 to 240 of about 3,751,417 (261)

Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

DNA Repair, 2008
Laboratory diagnosis for DNA repair diseases has been performed in western Europe from the early seventies for xeroderma pigmentosum (XP) and from the mid-eighties for Cockayne syndrome (CS) and trichothiodystrophy (TTD). The combined data from the DNA repair diagnostic centres in France, (West) Germany, Italy, the Netherlands and the United Kingdom ...
Kleijer, Wim J, Laugel, Vincent, Berneburg, Mark, Nardo, Tiziana, Fawcett, Heather, Gratchev, Alexei, Jaspers, Nicolaas G J, Sarasin, Alain, Stefanini, Miria, Lehmann, Alan R   +9 more
openaire   +3 more sources

Heritable Radiosensitive and DNA Repair-Deficient Disorders in Man

1981
The deleterious effects of many environmental agents--ultraviolet (UV) light, ionizing radiation, and polycyclic aromatic hydrocarbons, to cite a few--are primarily attributed to their ability to react with, and thereby structurally modify the deoxyribonucleic acid (DNA) of the living cell1.
M. C. Paterson, N. T. Bech-Hansen, P. J. Smith   +2 more
openaire   +1 more source

Response to environmental carcinogens in DNA-repair-deficient disorders

Toxicology, 2003
An increased mutation rate in human cells is a critical contributing factor for the development of malignancy. Many autosomal recessive genetic disorders are known, in which an increased mutation rate and predisposition for cancer can be attributed to a deficiency in DNA repair or associated processes.
openaire   +2 more sources

Heritable cancer-prone disorders featuring carcinogen hypersensitivity and DNA repair deficiency.

IARC scientific publications, 1983
The clinical and laboratory studies on the disorders discussed here have yielded considerable insight into the importance of DNA repair processes in man. That unrepaired or incorrectly repaired damage to DNA can lead to malignancy and compromise the proper development and functioning of the nervous and immune systems is a reasonable conclusion.
openaire   +1 more source

Hprt mutations in the DNA of cells from patients with repair-deficient disorders

Mutation Research/Environmental Mutagenesis and Related Subjects, 1989
J. Cole, A. Lehmann
openaire   +1 more source