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Heritable cancer-prone disorders featuring carcinogen hypersensitivity and DNA repair deficiency.
IARC scientific publications, 1983The clinical and laboratory studies on the disorders discussed here have yielded considerable insight into the importance of DNA repair processes in man. That unrepaired or incorrectly repaired damage to DNA can lead to malignancy and compromise the proper development and functioning of the nervous and immune systems is a reasonable conclusion.
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Hprt mutations in the DNA of cells from patients with repair-deficient disorders
Mutation Research/Environmental Mutagenesis and Related Subjects, 1989J. Cole, A. Lehmann
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Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
Nature Reviews Molecular Cell Biology, 2023Samah Awwad +2 more
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C054 DNA repair deficient disorders
Journal of the European Academy of Dermatology and Venereology, 1997openaire +1 more source
Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer
Nature, 2022Raymond J Noonan +2 more
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Bacterial DNA excision repair pathways
Nature Reviews Microbiology, 2022Katherine J Wozniak, Lyle A Simmons
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap, Johann Sebastian de Bono
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TFIIH: when transcription met DNA repair
Nature Reviews Molecular Cell Biology, 2012Emmanuel Compe
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DNA double-strand break repair-pathway choice in somatic mammalian cells
Nature Reviews Molecular Cell Biology, 2019Ralph Scully +2 more
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