Results 11 to 20 of about 528,873 (274)

RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice

Neurobiology of Disease, 2023
RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA replication, recombination, and DNA repair. In human cells, there are five RecQ helicases: RECQL1, Bloom syndrome (BLM), Werner syndrome (WRN), RECQL4, and ...
Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L. Croteau, Vilhelm A. Bohr   +7 more
doaj  

GEN1 promotes common fragile site expression

Cell Reports, 2023
Summary: Our genomes harbor conserved DNA sequences, known as common fragile sites (CFSs), that are difficult to replicate and correspond to regions of genome instability.
Anaid Benitez, Marie Sebald, Radhakrishnan Kanagaraj, Monica C. Rodrigo-Brenni, Ying Wai Chan, Chih-Chao Liang, Stephen C. West   +6 more
doaj  

Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN

Journal of Experimental & Clinical Cancer Research, 2021
Background Colorectal cancer (CRC) represents the fourth leading cause of cancer-related deaths. The heterogeneity of CRC identity limits the usage of cell lines to study this type of tumor because of the limited representation of multiple features of ...
Marta Codrich, Emiliano Dalla, Catia Mio, Giulia Antoniali, Matilde Clarissa Malfatti, Stefania Marzinotto, Mariaelena Pierobon, Elisa Baldelli, Carla Di Loreto, Giuseppe Damante, Giovanni Terrosu, Carlo Ennio Michele Pucillo, Gianluca Tell   +12 more
doaj   +1 more source

Chargaff’s second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible [PDF]

PeerJ, 2023
Background Francis Crick’s central dogma provides a residue-by-residue mechanistic explanation of the flow of genetic information in living systems.
Bakhyt T. Matkarimov, Murat K. Saparbaev
doaj   +2 more sources

Charge transport-mediated recruitment of DNA repair enzymes [PDF]

Journal of Chemical Physics, 129, 235101, (2008), 2008
Damaged or mismatched bases in DNA can be repaired by Base Excision Repair (BER) enzymes that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin, {\it et al.}, PNAS, {\bf 102}, 3546, (2005 ...
arxiv   +1 more source

Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

eLife, 2015
Holliday junctions (HJs) are key DNA intermediates in homologous recombination. They link homologous DNA strands and have to be faithfully removed for proper DNA segregation and genome integrity.
Shun-Hsiao Lee, Lissa Nicola Princz, Maren Felizitas Klügel, Bianca Habermann, Boris Pfander, Christian Biertümpfel   +5 more
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Nature Communications, 2017
Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose ...
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman   +12 more
doaj   +1 more source

lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons

Cells, 2023
Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC ...
Vincent E. Provasek, Manohar Kodavati, Wenting Guo, Haibo Wang, Istvan Boldogh, Ludo Van Den Bosch, Gavin Britz, Muralidhar L. Hegde   +7 more
doaj   +1 more source

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Nature Communications, 2018
Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose ...
Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman   +10 more
doaj   +1 more source

Putative Role of the Futile Repair Initiated by Human Thymine-DNA Glycosylase in Formation of Programmed Strand Breaks in Neuronal Enhancers [PDF]

BIO Web of Conferences
Enhancers are regulatory DNA elements that play a crucial role in controlling gene expression in specific cell types, including neurons. Enhancer activity is tightly regulated and involves the recruitment of various proteins and enzymes to facilitate the
Manapkyzy Diana, Saparbaev Murat, Taipakova Sabira   +2 more
doaj   +1 more source