Results 191 to 200 of about 981,272 (286)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

AMPK phosphorylates WIP1 to promote DNA repair and radioresistance in cancer cells. [PDF]

Cell Death Dis
Lu M, Dong X, Wu C, Wang G, Wang H, Pan Y, Qin Y, Song Y, Pan H, Liu S, Zhang K, Zhang X, Qu J, Yang Z.   +13 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

LMNA-PRKDC axis enhances DNA repair and promotes chemoresistance in glioblastoma. [PDF]

Cell Death Dis
Saathoff MR, Chojak R, Chen RX, Kazi HA, Faisal UH, Shireman JM, Drewes N, Park CH, Fan X, Khan SA, Lazanyi I, Baisiwala S, James CD, Horbinski CM, Ahmed AU.   +14 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation. [PDF]

Cell Rep
Nebenfuehr B, Sanford L, Taylor ER, Ball K, Woods-Killam CE, Ghasemi HI, Proctor B, Ortega R, Sempeck C, Dowell RD, Arnoult N.   +10 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways. [PDF]

Nat Commun
Feng J, Martin PR, Kowalski S, Lecot M, Cronin NB, Matthews-Palmer T, Niedzwiedz W, Greber BJ.   +7 more
europepmc   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Targeting TDP1 phosphorylation by the natural product imperatorin promotes DNA repair and cardiac regeneration. [PDF]

Commun Biol
Fu W, Hou L, Yang X, Wang J, Jin J, Tong Q.   +5 more
europepmc   +1 more source