Results 221 to 230 of about 1,028,456 (338)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.)

Haematologica, 2019
Naiara Santana-Codina, Sebastian Gableske, Mark D. Fleming, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias   +5 more
doaj   +1 more source

The alternative lengthening of telomeres pathway through a DNA repair lens: mechanism and therapeutic opportunities. [PDF]

NAR Cancer
Muoio D, Fouquerel E.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals. [PDF]

Adv Sci (Weinh)
Zhai T, Mazzucato P, Ricciardi C, Christiani DC, Liang L, Samson LD, Chaim IA, Nagel ZD.   +7 more
europepmc   +1 more source

DNA repair comes of age

, 1995
Philip C. Hanawalt
openalex   +1 more source

P1.04-22 Potential DNA Repair Biomarker for Response to Immunotherapy of Lung Cancer Patients [PDF]

, 2019
Zvi Livneh, Tamar Paz-Elizur, Yael Leitner‐Dagan, Kerstin B. Meyer, Barak Markus, Federico M. Giorgi, Martin O’Reilly, H. Kim, Yentl Evgy, Robert C. Rintoul, B. Ponder   +10 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

DNA repair helicases: from mechanistic understanding to therapeutic implications. [PDF]

NAR Cancer
Menon V, Gueble SE.
europepmc   +1 more source

Into the eye of the storm: breast cancer's somatic mutation landscape points to DNA damage and repair.

, 2013
Joanne Ngeow, Emily Nizialek, Charis Eng
openalex   +1 more source