Results 221 to 230 of about 981,272 (286)

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients with Extra‐Renal Systemic Lupus Erythematosus – A Systematic Review & Meta‐analysis

Arthritis Care &Research, Accepted Article.
Background Clinical response to Mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with SLE, particularly those with extra‐renal ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

YEATS2 promotes DNA repair and induces anoikis resistance by enhancing chromatin accessibility to drive prostate cancer metastasis. [PDF]

Oncogene
Li H, Song Y, Cong Y, Wang C, Chen K, Liu C, Zhou M, Ju Y, Chen J, Chen L, Xing Y.   +10 more
europepmc   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma. [PDF]

Cell Commun Signal
Rajaratnam S, Piyarathna DWB, Mehta RK, Mekala V, Park JH, Rasaily U, Venkatappa V, Kami Reddy KR, Putluri V, Goel K, Grimm SL, Thota SM, Morrison T, Coarfa C, Kaipparettu BA, Cheng C, Putluri N, Jones JA, Nyati MK, Ittmann M, Gassman NR, Sreekumar A.   +21 more
europepmc   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Regulation of DNA repair gene expression by PRMT5. [PDF]

MicroPubl Biol
Bliss H, Bouley RA, Petreaca RC.
europepmc   +1 more source

Selective and Precise Editing of Digital Polymers Through Parallel or Series Toehold‐Mediated Strand Displacement

Advanced Functional Materials, EarlyView.
A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski, Cyril Antheaume, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +1 more source

Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms. [PDF]

Blood Cancer J
Meyer R, Rodriguez MJ, Caduc M, Kricheldorf K, Begemann M, Kraft F, Spier I, Dey D, Güzel N, Becker K, Baumeister J, S de Toledo MA, Isfort S, Germing U, Aretz S, Brümmendorf TH, Kurth I, Elbracht M, Teichmann LL, Koschmieder S.   +19 more
europepmc   +1 more source

On‐Surface Indigo‐Based Bimolecular Coordination Networks with Programmable Regular or Vitreous Structure

Advanced Functional Materials, EarlyView.
A previously unreported coordination motif stabilising single Fe atoms by indigo chelation and pyridyl coordination on Au(111) has been revealed. By using planar tritopic pyridyl linkers (TPyB), extended 2D porous networks of indigo3(TPyB)2Fe6 form. These networks can be crystalline or vitreous and offer an environment where individual coordination ...
Hongxiang Xu, Ritam Chakraborty, Biao Yang, Dennis Meier, Joachim Reichert, Svetlana Klyatskaya, Mario Ruben, Shobhana Narasimhan, Johannes V. Barth, Anthoula C. Papageorgiou   +9 more
wiley   +1 more source

Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair. [PDF]

Nat Commun
Jiang Y, Przybilla M, Bakker L, Jacobs FC, Mckeon D, van der Sluijs R, Sato K, Wezenbeek J, van Strien J, Willems J, Verkennis AEE, Barnett J, Ortega AB, Abascal F, Villalta PW, Knipscheer P, Martincorena I, Balbo S, Garaycoechea J.   +18 more
europepmc   +1 more source