Results 21 to 30 of about 953,901 (365)
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1
Nature Communications, 2023 Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek +7 more
doaj +1 more source
DNA repair and carcinogenesis [PDF]
BioDiscovery, 2014 The paper is dedicated to the natural phenomenon of cancer, with its possible causes, lifetime risks, mechanisms and possible outcomes discussed in fine detail. The molecular events resulting in uncontrolled cell growth and increased capacity to colonise distant topological sites are reviewed with regards to their impact as separate factors as well as ...
Chakarov,Stoyan +3 more
openaire +4 more sources
DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae [PDF]
, 1995 The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiation was studied by analysis of postirradiation molecular weight changes in cellular DNA.
Budd, Martin E., Campbell, Judith L.
core +2 more sources
RNase H enables efficient repair of R-loop induced DNA damage. [PDF]
, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core +1 more source
DNA REPAIR. Drugging DNA repair.
Science (New York, N.Y.), 2016 Inhibiting DNA repair can have a positive outcome on therapeutic ...
Jackson, Stephen P, Helleday, Thomas
openaire +2 more sources
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]
, 2010 Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah +9 more
core +1 more source
Personalized genome structure via single gamete sequencing
Genome Biology, 2021 Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s genome,
Ruqian Lyu +3 more
doaj +1 more source
Biomolecular Concepts, 2020 Liquid-liquid phase separation (LLPS) is a way to concentrate biochemical reactions while excluding noninteracting components. Disordered domains of proteins, as well as interaction with RNA, favor condensation but are not mandatory for modulating this ...
Tosolini Damiano +3 more
doaj +1 more source
Frontiers in Oncology, 2023 BackgroundXeroderma pigmentosum (XP), a rare disease with defects in DNA repair genes, has >1,000-fold increased risk of ultraviolet-induced skin cancers.
Elvelyn R. Fernandez +7 more
doaj +1 more source
BioDiscovery, 2014 This paper provides detailed insight into the mechanisms of repair of different types of DNA damage and the direct molecular players (enzymes repairing the damage or tagging the damaged site for further processing; damage sensor molecules; other signalling and effector molecules).
Chakarov,Stoyan +2 more
openaire +5 more sources