Results 21 to 30 of about 981,272 (286)
Frontiers in Oncology, 2023 BackgroundXeroderma pigmentosum (XP), a rare disease with defects in DNA repair genes, has >1,000-fold increased risk of ultraviolet-induced skin cancers.
Elvelyn R. Fernandez +7 more
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RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
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Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. [PDF]
, 2009 Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular ...
Cook, Peter J +5 more
core +2 more sources
Annual Review of Biochemistry, 1996 In nucleotide excision repair DNA damage is removed through incision of the damaged strand on both sides of the lesion, followed by repair synthesis, which fills the gap using the intact strand as a template, and finally ligation. In prokaryotes the damaged base is removed in a 12-13 nucleotide (nt)-long oligomer; in eukaryotes including humans the ...
openaire +2 more sources
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells [PDF]
, 2010 Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts.
Cloney, Ross +13 more
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DNA REPAIR. Drugging DNA repair.
Science (New York, N.Y.), 2016 Inhibiting DNA repair can have a positive outcome on therapeutic interventions All the cells in our bodies suffer many thousands of DNA lesions every day ( 1 ). The vast majority of these lesions are safely dealt with by cellular DNA repair and associated DNA damage response (DDR) activities that are, as a consequence, vital for life.
Jackson, Stephen P, Helleday, Thomas
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Journal of Experimental & Clinical Cancer Research, 2021 Background Colorectal cancer (CRC) represents the fourth leading cause of cancer-related deaths. The heterogeneity of CRC identity limits the usage of cell lines to study this type of tumor because of the limited representation of multiple features of ...
Marta Codrich +12 more
doaj +1 more source
Molecular Determinant of DIDS Analogs Targeting RAD51 Activity
Molecules, 2021 RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments.
Denis Velic +6 more
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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]
, 2012 The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma +36 more
core +1 more source
DNA demethylation by DNA repair [PDF]
Trends in Genetics, 2009 Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process.
Gehring, Mary +2 more
openaire +3 more sources