Results 21 to 30 of about 3,766,607 (390)
Loop extrusion as a mechanism for DNA damage repair foci formation
Nature, 2021 The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX
C. Arnould +12 more
semanticscholar +1 more source
Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
Communications Biology, 2020 Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype.
Gloria X. Reyes +5 more
doaj +1 more source
Cellular and Molecular Life Sciences (CMLS), 2004 Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and endogenous agents or introduced by DNA metabolism, such as replication. Most repair mechanisms include nucleolytic processing of DNA, where nucleases cleave a phosphodiester bond between a deoxyribose and a phosphate residue ...
Oliver Fleck +2 more
openaire +5 more sources
Optimality in DNA repair [PDF]
Journal of Theoretical Biology, 2012 DNA within cells is subject to damage from various sources. Organisms have evolved a number of mechanisms to repair DNA damage. The activity of repair enzymes carries its own risk, however, because the repair of two nearby lesions may lead to the breakup of DNA and result in cell death.
Richard, Morgiane Carole +5 more
openaire +3 more sources
Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration.
Xixia Chu +9 more
doaj +1 more source
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1
Nature Communications, 2023 Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss of the nucleotide salvage factor DNPH1 there is considerable interest in the ...
Neil J. Rzechorzek +7 more
doaj +1 more source
DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae [PDF]
, 1995 The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiation was studied by analysis of postirradiation molecular weight changes in cellular DNA.
Budd, Martin E., Campbell, Judith L.
core +2 more sources
DNA REPAIR. Drugging DNA repair.
Science (New York, N.Y.), 2016 Inhibiting DNA repair can have a positive outcome on therapeutic ...
Jackson, Stephen P, Helleday, Thomas
openaire +2 more sources
Biomolecular Concepts, 2020 Liquid-liquid phase separation (LLPS) is a way to concentrate biochemical reactions while excluding noninteracting components. Disordered domains of proteins, as well as interaction with RNA, favor condensation but are not mandatory for modulating this ...
Tosolini Damiano +3 more
doaj +1 more source
Personalized genome structure via single gamete sequencing
Genome Biology, 2021 Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s genome,
Ruqian Lyu +3 more
doaj +1 more source